A Synthetic Epoxydocosapentaenoic Acid Analogue Ameliorates Cardiac Ischemia/Reperfusion Injury: The Involvement of the Sirtuin 3-NLRP3 Pathway

While survival rates have markedly improved following cardiac ischemia-reperfusion (IR) injury, the resulting heart damage remains an important issue. Preserving mitochondrial quality and limiting NLRP3 inflammasome activation is an approach to limit IR injury, in which the mitochondrial deacetylase...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (15), p.5261
Hauptverfasser:	Darwesh, Ahmed M, Bassiouni, Wesam, Adebesin, Adeniyi Michael, Mohammad, Abdul Sattar, Falck, John R, Seubert, John M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Activation Animals Antioxidants Attenuation Cytochrome P450 Cytochromes P450 Docosahexaenoic acid Docosahexaenoic Acids - analogs & derivatives Docosahexaenoic Acids - chemical synthesis Docosahexaenoic Acids - chemistry Docosahexaenoic Acids - pharmacology Enzymes Female Heart Homeostasis Inflammasomes Injury prevention Ischemia Male Manganese Metabolites Mice Mitochondria Myocardial Reperfusion Injury - drug therapy Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - pathology Myocardium - metabolism Myocardium - pathology NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxidative stress Oxidative Stress - drug effects Preservation Proteins Recovery of function Reperfusion Sirtuin 3 - metabolism Superoxide dismutase
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!