Aesculetin Attenuates Alveolar Injury and Fibrosis Induced by Close Contact of Alveolar Epithelial Cells with Blood-Derived Macrophages via IL-8 Signaling

Pulmonary fibrosis is a disease in which lung tissues become fibrous and thereby causes severe respiratory disturbances. Various stimuli induce infiltration of macrophages to the respiratory tract, secreting inflammatory cytokines, which subsequently leads to the development of pulmonary fibrosis. A...

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Veröffentlicht in:	International journal of molecular sciences 2020-08, Vol.21 (15), p.5518
Hauptverfasser:	Oh, Su Yeon, Kim, Yun-Ho, Kang, Min-Kyung, Lee, Eun-Jung, Kim, Dong Yeon, Oh, Hyeongjoo, Kim, Soo-Il, Na, Woojin, Kang, Young-Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Alveolar Epithelial Cells - drug effects Alveolar Epithelial Cells - metabolism Alveolar Epithelial Cells - pathology Alveoli Animals Antioxidants Asthma Bronchus Chemokines Chicory Chronic obstructive pulmonary disease Collagen CXCR2 protein Cytokines Cytotoxicity Disruption Epithelial cells Epithelial-Mesenchymal Transition - drug effects Fibrosis Guanidine Humans Inflammation Inhalation Interleukin 8 Interleukin-8 - metabolism Ligands Lung diseases Lungs Macrophages Macrophages - metabolism Male Markers Matrix metalloproteinase Matrix metalloproteinases Mesenchyme Metalloproteinase Metastases Mice, Inbred BALB C Monocytes Neutrophils Pathogenesis Proteins Pulmonary Alveoli - drug effects Pulmonary Alveoli - metabolism Pulmonary Alveoli - pathology Pulmonary fibrosis Pulmonary Fibrosis - metabolism Pulmonary Fibrosis - pathology Pulmonary Fibrosis - prevention & control Respiration Respiratory tract Signal Transduction - drug effects THP-1 Cells Tissue inhibitor of metalloproteinases Tumor necrosis factor-α Umbelliferones - pharmacology
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