The aged hematopoietic system promotes hippocampal‐dependent cognitive decline

The aged systemic milieu promotes cellular and cognitive impairments in the hippocampus. Here, we report that aging of the hematopoietic system directly contributes to the pro‐aging effects of old blood on cognition. Using a heterochronic hematopoietic stem cell (HSC) transplantation model (in which...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Aging cell 2020-08, Vol.19 (8), p.e13192-n/a
Hauptverfasser:	Smith, Lucas K., Verovskaya, Evgenia, Bieri, Gregor, Horowitz, Alana M., von Ungern‐Sternberg, Saskia N. I., Lin, Karin, Seizer, Peter, Passegué, Emmanuelle, Villeda, Saul A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aging Aging - pathology Animals Blood Cognition Cognition & reasoning Cognitive ability Cognitive Dysfunction - physiopathology cyclophilin A Hematopoietic stem cells Hematopoietic Stem Cells - pathology hematopoietic system Hippocampus Hippocampus - physiopathology Male Mass spectrometry Memory Mice Neurogenesis Phosphorylation Plasma Rodents Scientific imaging Short Take Stem cells Transplantation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!