A Genome-Wide CRISPR-Cas9 Screen Reveals the Requirement of Host Cell Sulfation for Schmallenberg Virus Infection

Schmallenberg virus (SBV) is an insect-transmitted orthobunyavirus that can cause abortions and congenital malformations in the offspring of ruminants. Even though the two viral surface glycoproteins Gn and Gc are involved in host cell entry, the specific cellular receptors of SBV are currently unkn...

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Veröffentlicht in:	Journal of virology 2020-08, Vol.94 (17)
Hauptverfasser:	Thamamongood, Thiprampai, Aebischer, Andrea, Wagner, Valentina, Chang, Max W, Elling, Roland, Benner, Christopher, García-Sastre, Adolfo, Kochs, Georg, Beer, Martin, Schwemmle, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bunyaviridae Bunyaviridae Infections - genetics Bunyaviridae Infections - virology Chlorocebus aethiops Clustered Regularly Interspaced Short Palindromic Repeats CRISPR-Cas Systems Europe Gene Knockout Techniques HEK293 Cells Heparitin Sulfate - metabolism Humans Livestock Membrane Glycoproteins - genetics Orthobunyavirus - genetics Orthobunyavirus - pathogenicity Orthobunyavirus - physiology Rift Valley fever virus Sulfate Transporters - metabolism Sulfotransferases - metabolism Vero Cells Virus Attachment Virus-Cell Interactions
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