Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence

Eastern equine encephalitis virus (EEEV) is the most pathogenic member of the genus in the family. This virus continues to circulate in the New World and has a potential for deliberate use as a bioweapon. Despite the public health threat, to date no attenuated EEEV variants have been applied as live...

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Veröffentlicht in:	Journal of virology 2020-08, Vol.94 (17)
Hauptverfasser:	Meshram, Chetan D, Shiliaev, Nikita, Frolova, Elena I, Frolov, Ilya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Neutralizing Binding Sites Capsid Proteins - genetics Cell Line Encephalitis Virus, Eastern Equine - genetics Encephalitis Virus, Eastern Equine - immunology Encephalitis Virus, Eastern Equine - pathogenicity Encephalomyelitis, Equine - immunology Encephalomyelitis, Equine - prevention & control Mice Mutation Pathogenesis and Immunity Vaccines, Attenuated - immunology Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Virulence - genetics Virulence - immunology Virulence Factors - genetics Virulence Factors - immunology Virus Replication
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