Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities

Maternal immune activation (MIA) disrupts the central innate immune system during a critical neurodevelopmental period. Microglia are primary innate immune cells in the brain although their direct influence on the MIA phenotype is largely unknown. Here we show that MIA alters microglial gene express...

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Veröffentlicht in:	Molecular psychiatry 2021-06, Vol.26 (6), p.1808-1831
Hauptverfasser:	Ikezu, Seiko, Yeh, Hana, Delpech, Jean-Christophe, Woodbury, Maya E., Van Enoo, Alicia A., Ruan, Zhi, Sivakumaran, Sudhir, You, Yang, Holland, Carl, Guillamon-Vivancos, Teresa, Yoshii-Kitahara, Asuka, Botros, Mina B., Madore, Charlotte, Chao, Pin-Hao, Desani, Ankita, Manimaran, Solaiappan, Kalavai, Srinidhi Venkatesan, Johnson, W. Evan, Butovsky, Oleg, Medalla, Maria, Luebke, Jennifer I., Ikezu, Tsuneya
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/51 14/19 14/32 14/63 14/69 38/91 631/337 631/378 64/60 692/699/476/1373 96/31 Animals Axonogenesis Behavior, Animal Behavioral Sciences Biological Psychology Brain Cell receptors Child development deviations Colonies Colony-stimulating factor Colony-stimulating factors (Physiology) Complications and side effects Dendritic spines Development and progression Developmental disabilities Disease Models, Animal Female Fetus Gene expression Growth Health aspects Immune response Immune system Inflammation Innate immunity Life Sciences Macrophage Colony-Stimulating Factor Medicine Medicine & Public Health Mental illness Mice Microglia Neurons Neurons and Cognition Neurosciences Perinatal infection Pharmacotherapy Phenotypes Physiological aspects Prefrontal cortex Pregnancy Prenatal Exposure Delayed Effects Prenatal influences Psychiatry Pyramidal cells Receptors, Granulocyte-Macrophage Colony-Stimulating Factor Risk factors Social behavior
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