Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS

With roughly 2 billion people infected, the neurotropic protozoan Toxoplasma gondii remains one of the most pervasive and infectious parasites. Toxoplasma infection is the second leading cause of death due to foodborne illness in the United States, causes severe disease in immunocompromised patients...

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Veröffentlicht in:	ACS chemical neuroscience 2020-08, Vol.11 (16), p.2450-2463
Hauptverfasser:	Zwicker, Jeffery D, Smith, David, Guerra, Alfredo J, Hitchens, Jacob R, Haug, Nicole, Vander Roest, Steve, Lee, Pil, Wen, Bo, Sun, Duxin, Wang, Lu, Keep, Richard F, Xiang, Jianming, Carruthers, Vern B, Larsen, Scott D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cathepsin L Central Nervous System Humans Mice Nitriles - pharmacology Protozoan Proteins Toxoplasma Toxoplasmosis - drug therapy Triazines - pharmacology
Online-Zugang:	Volltext
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