Co-option of the lineage-specific LAVA retrotransposon in the gibbon genome

Co-option of transposable elements (TEs) to become part of existing or new enhancers is an important mechanism for evolution of gene regulation. However, contributions of lineage-specific TE insertions to recent regulatory adaptations remain poorly understood. Gibbons present a suitable model to stu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-08, Vol.117 (32), p.19328-19338
Hauptverfasser:	Okhovat, Mariam, Nevonen, Kimberly A., Davis, Brett A., Michener, Pryce, Ward, Samantha, Milhaven, Mark, Harshman, Lana, Sohota, Ajuni, Fernandes, Jason D., Salama, Sofie R., O’Neill, Rachel J., Ahituv, Nadav, Veeramah, Krishna R., Carbonea, Lucia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptation Animals Biological Sciences Cell cycle Chromatin Chromatin - genetics Deoxyribonucleic acid DNA DNA damage DNA repair Enhancers Evolution Evolution, Molecular Gene expression Gene Expression Regulation Gene regulation Genes Genome Genomes Hylobates - classification Hylobates - genetics Mutagenesis, Insertional Mutation Positive selection PU.1 protein Regulatory sequences Regulatory Sequences, Nucleic Acid Retroelements Species Specificity Transcription factors
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