RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology

Infection by malaria parasites triggers dynamic immune responses leading to diverse symptoms and pathologies; however, the molecular mechanisms responsible for these reactions are largely unknown. We performed Trans-species Expression Quantitative Trait Locus analysis to identify a large number of h...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2020-08, Vol.117 (32), p.19465-19474
Hauptverfasser:	He, Xiao, Ashbrook, Alison W., Du, Yang, Wu, Jian, Hoffmann, Hans-Heinrich, Zhang, Cui, Xia, Lu, Peng, Yu-Chih, Tumas, Keyla C., Singh, Brajesh K., Qi, Chen-feng, Myers, Timothy G., Long, Carole A., Liu, Chengyu, Wang, Rongfu, Rice, Charles M., Su, Xin-zhuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Brain Brain - parasitology Brain - pathology Brain - virology Gene mapping Genes HEK293 Cells Host-Pathogen Interactions Humans Immune response Infections Interferon Interferon Regulatory Factor-3 Interferon Type I - metabolism Kinases Malaria Malaria, Cerebral - metabolism Malaria, Cerebral - parasitology Malaria, Cerebral - pathology Membrane Proteins Mice Mice, Inbred C57BL Mice, Knockout Microglia Microglia - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Molecular modelling Neuropathology Parasitemia Parasites Phosphorylation Plasmodium berghei - physiology Plasmodium yoelii - physiology Protein Binding Protein transport Protein-Serine-Threonine Kinases - metabolism Quantitative trait loci Signal Transduction Signs and symptoms Spleen Survival Vector-borne diseases Viruses West Nile Fever - metabolism West Nile Fever - pathology West Nile Fever - virology West Nile virus West Nile virus - physiology
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