REM sleep stabilizes hypothalamic representation of feeding behavior
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2020-08, Vol.117 (32), p.19590-19598 |
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| container_issue | 32 |
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| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Oesch, Lukas T. Gazea, Mary Gent, Thomas C. Bandarabadi, Mojtaba Herrera, Carolina Gutierrez Adamantidis, Antoine R. |
| description | During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior. |
| doi_str_mv | 10.1073/pnas.1921909117 |
| format | Article |
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Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.1921909117</identifier><identifier>PMID: 32732431</identifier><language>eng</language><publisher>United States: National Academy of Sciences</publisher><subject>Activity patterns ; Animal behavior ; Animals ; Biological Sciences ; Brain Mapping ; Calcium imaging ; Feeding behavior ; Feeding Behavior - physiology ; Food intake ; Hypothalamic Area, Lateral - physiology ; Hypothalamus ; Hypothalamus (lateral) ; Male ; Mice ; Nerve Net ; Neural Inhibition ; Neural networks ; Neuroimaging ; Neurons - metabolism ; Neurons - physiology ; Optogenetics ; REM sleep ; Representations ; Sleep ; Sleep - physiology ; Sleep, REM - physiology ; Vesicular Inhibitory Amino Acid Transport Proteins - genetics ; Vesicular Inhibitory Amino Acid Transport Proteins - metabolism</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 2020-08, Vol.117 (32), p.19590-19598</ispartof><rights>Copyright © 2020 the Author(s). Published by PNAS.</rights><rights>Copyright National Academy of Sciences Aug 11, 2020</rights><rights>Copyright © 2020 the Author(s). 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| subjects | Activity patterns Animal behavior Animals Biological Sciences Brain Mapping Calcium imaging Feeding behavior Feeding Behavior - physiology Food intake Hypothalamic Area, Lateral - physiology Hypothalamus Hypothalamus (lateral) Male Mice Nerve Net Neural Inhibition Neural networks Neuroimaging Neurons - metabolism Neurons - physiology Optogenetics REM sleep Representations Sleep Sleep - physiology Sleep, REM - physiology Vesicular Inhibitory Amino Acid Transport Proteins - genetics Vesicular Inhibitory Amino Acid Transport Proteins - metabolism |
| title | REM sleep stabilizes hypothalamic representation of feeding behavior |
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