Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway
Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-7 |
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| creator | Zhao, Jingjing Pang, Xiaoming Liu, Juntian Zhang, Xiaolu Xu, Shouzhu |
| description | Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin. |
| doi_str_mv | 10.1155/2020/3245653 |
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Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2020/3245653</identifier><identifier>PMID: 32831861</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Aldosterone ; Anti-inflammatory diet ; Antibodies ; Arteriosclerosis ; Atherosclerosis ; C-reactive protein ; Chronic illnesses ; Coronary vessels ; Corticosteroids ; Curcumin ; Endocrine disorders ; Extracellular signal-regulated kinase ; Inflammation ; Inflammatory diseases ; Kinases ; Laboratory animals ; Molecular modelling ; Pathogenesis ; Phenylbutazone ; Proteins ; Reactive oxygen species ; Signal transduction ; Smooth muscle ; Variance analysis</subject><ispartof>Evidence-based complementary and alternative medicine, 2020, Vol.2020 (2020), p.1-7</ispartof><rights>Copyright © 2020 Xiaolu Zhang et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Xiaolu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Xiaolu Zhang et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-1f65389740214283fd723c82f78aed5a9a83e5da080ec8d8d70c8fa876d318e13</citedby><cites>FETCH-LOGICAL-c476t-1f65389740214283fd723c82f78aed5a9a83e5da080ec8d8d70c8fa876d318e13</cites><orcidid>0000-0002-1517-827X ; 0000-0002-4624-7506</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428966/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7428966/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Chuang, Shuang-En</contributor><creatorcontrib>Zhao, Jingjing</creatorcontrib><creatorcontrib>Pang, Xiaoming</creatorcontrib><creatorcontrib>Liu, Juntian</creatorcontrib><creatorcontrib>Zhang, Xiaolu</creatorcontrib><creatorcontrib>Xu, Shouzhu</creatorcontrib><title>Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway</title><title>Evidence-based complementary and alternative medicine</title><description>Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.</description><subject>Aldosterone</subject><subject>Anti-inflammatory diet</subject><subject>Antibodies</subject><subject>Arteriosclerosis</subject><subject>Atherosclerosis</subject><subject>C-reactive protein</subject><subject>Chronic illnesses</subject><subject>Coronary vessels</subject><subject>Corticosteroids</subject><subject>Curcumin</subject><subject>Endocrine disorders</subject><subject>Extracellular signal-regulated kinase</subject><subject>Inflammation</subject><subject>Inflammatory diseases</subject><subject>Kinases</subject><subject>Laboratory animals</subject><subject>Molecular modelling</subject><subject>Pathogenesis</subject><subject>Phenylbutazone</subject><subject>Proteins</subject><subject>Reactive oxygen species</subject><subject>Signal transduction</subject><subject>Smooth muscle</subject><subject>Variance analysis</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0k9rFDEYBvBBFFurN88S8CLo2PyZmWQuhWWpdbHSsqviLbwm7-ymzCZrMtOl38KPbNZdWvTiKYH88iQPvEXxktH3jNX1Kaecngpe1U0tHhXHTFasrLhSj-_38vtR8SylG0p5K6V8WhwJrgRTDTsufk3HaMa182QxbjYRU8JEJr0NacAYPJYzb0eDlkzn1-QCPUYYXPAkX5jDQL5BMmMPkSzWIQwr8nlMpkcyxb5P5NYBmfmc02F0fkm2LothhWR-tSjP55_YKScLt_TQ706vYVht4e558aSDPuGLw3pSfP1w_mX6sby8uphNJ5elqWQzlKzLdVUrK8pZbis6K7kwindSAdoaWlACawtUUTTKKiupUR0o2djcHJk4Kc72uZvxxxqtQT9E6PUmujXEOx3A6b9PvFvpZbjVMj_XNk0OeHMIiOHniGnQa5dMLg4ew5g0r0SjJOeKZvr6H3oTxph7_1FVRWvWVg9qCT1q57uQ3zW7UD1pRNu2VSPbrN7tlYkhpYjd_ZcZ1buB0LuB0IeByPztnq-ct7B1_9Ov9hqzwQ4edKZNXYvf_XW9Lw</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Zhao, Jingjing</creator><creator>Pang, Xiaoming</creator><creator>Liu, Juntian</creator><creator>Zhang, Xiaolu</creator><creator>Xu, Shouzhu</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1517-827X</orcidid><orcidid>https://orcid.org/0000-0002-4624-7506</orcidid></search><sort><creationdate>2020</creationdate><title>Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway</title><author>Zhao, Jingjing ; Pang, Xiaoming ; Liu, Juntian ; Zhang, Xiaolu ; Xu, Shouzhu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-1f65389740214283fd723c82f78aed5a9a83e5da080ec8d8d70c8fa876d318e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Aldosterone</topic><topic>Anti-inflammatory diet</topic><topic>Antibodies</topic><topic>Arteriosclerosis</topic><topic>Atherosclerosis</topic><topic>C-reactive protein</topic><topic>Chronic illnesses</topic><topic>Coronary vessels</topic><topic>Corticosteroids</topic><topic>Curcumin</topic><topic>Endocrine disorders</topic><topic>Extracellular signal-regulated kinase</topic><topic>Inflammation</topic><topic>Inflammatory diseases</topic><topic>Kinases</topic><topic>Laboratory animals</topic><topic>Molecular modelling</topic><topic>Pathogenesis</topic><topic>Phenylbutazone</topic><topic>Proteins</topic><topic>Reactive oxygen species</topic><topic>Signal transduction</topic><topic>Smooth muscle</topic><topic>Variance analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Jingjing</creatorcontrib><creatorcontrib>Pang, Xiaoming</creatorcontrib><creatorcontrib>Liu, Juntian</creatorcontrib><creatorcontrib>Zhang, Xiaolu</creatorcontrib><creatorcontrib>Xu, Shouzhu</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest Psychology</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Jingjing</au><au>Pang, Xiaoming</au><au>Liu, Juntian</au><au>Zhang, Xiaolu</au><au>Xu, Shouzhu</au><au>Chuang, Shuang-En</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>7</epage><pages>1-7</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Aldosterone regulates the initiation and development of atherosclerosis which is identified as a chronic inflammatory disease by promoting the generation of C-reactive protein in vascular smooth muscle cells. Curcumin is the most active ingredient of turmeric with anti-inflammation and antioxidation effects. Here, the effect of curcumin on aldosterone-induced C-reactive protein generation in vascular smooth muscle and the molecular mechanisms involved were explored. Primary rat vascular smooth muscle cells and hyperaldosteronism model rats were used in this study. The amount of C-reactive protein, reactive oxygen species, and the signaling pathway-related molecules generated were estimated. We found that curcumin inhibited aldosterone-induced C-reactive protein generation in vascular smooth muscle cells by interfering with the reactive oxygen species-ERK1/2 signal pathway. The results provide new evidence for the potential anti-inflammatory and cardiovascular protective effects of curcumin.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>32831861</pmid><doi>10.1155/2020/3245653</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-1517-827X</orcidid><orcidid>https://orcid.org/0000-0002-4624-7506</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Open Access; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; PubMed Central Open Access |
| subjects | Aldosterone Anti-inflammatory diet Antibodies Arteriosclerosis Atherosclerosis C-reactive protein Chronic illnesses Coronary vessels Corticosteroids Curcumin Endocrine disorders Extracellular signal-regulated kinase Inflammation Inflammatory diseases Kinases Laboratory animals Molecular modelling Pathogenesis Phenylbutazone Proteins Reactive oxygen species Signal transduction Smooth muscle Variance analysis |
| title | Curcumin Suppresses Aldosterone-Induced CRP Generation in Rat Vascular Smooth Muscle Cells via Interfering with the ROS-ERK1/2 Signaling Pathway |
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