Spermidine Suppresses Development of Experimental Abdominal Aortic Aneurysms

Background The protective effects of polyamines on cardiovascular disease have been demonstrated in many studies. However, the roles of spermidine, a natural polyamine, in abdominal aortic aneurysm (AAA) disease have not been studied. In this study, we investigated the influence and potential mechan...

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Veröffentlicht in:	Journal of the American Heart Association 2020-04, Vol.9 (8), p.e014757, Article 014757
Hauptverfasser:	Liu, Shuai, Huang, Tingting, Liu, Rui, Cai, Huoying, Pan, Baihong, Liao, Mingmei, Yang, Pu, Wang, Lei, Huang, Jianhua, Ge, Yingbin, Xu, Baohui, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	abdominal aortic aneurysm Aged Animals Anti-Inflammatory Agents - pharmacology Aorta, Abdominal - drug effects Aorta, Abdominal - metabolism Aorta, Abdominal - ultrastructure Aortic Aneurysm, Abdominal - chemically induced Aortic Aneurysm, Abdominal - metabolism Aortic Aneurysm, Abdominal - pathology Aortic Aneurysm, Abdominal - prevention & control autophagy Autophagy - drug effects Autophagy-Related Proteins - metabolism Cardiac & Cardiovascular Systems Cardiovascular System & Cardiology Chemotaxis, Leukocyte - drug effects Dilatation, Pathologic Disease Models, Animal experimental animal models Female Humans inflammation Inflammation Mediators - metabolism Life Sciences & Biomedicine Male Mice, Inbred C57BL Middle Aged Original Research Pancreatic Elastase Science & Technology Signal Transduction spermidine Spermidine - pharmacology Vascular Remodeling - drug effects
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