A Common NLRC4 Gene Variant Associates With Inflammation and Pulmonary Function in Human Immunodeficiency Virus and Tuberculosis

Abstract Background Inflammasomes mediate inflammation in adults living with both human immunodeficiency virus (HIV) and tuberculosis (TB), but the relevance of inflammasome gene polymorphisms in TB-associated pulmonary damage is unknown. We hypothesized that functional single-nucleotide polymorphis...

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Veröffentlicht in:	Clinical infectious diseases 2020-08, Vol.71 (4), p.924-932
Hauptverfasser:	Ravimohan, Shruthi, Maenetje, Pholo, Auld, Sara C, Ncube, Itai, Mlotshwa, Mandla, Chase, William, Tiemessen, Caroline T, Vangu, Mboyo-Di-Tamba, Wallis, Robert S, Churchyard, Gavin, Weissman, Drew, Kornfeld, Hardy, Bisson, Gregory P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and Commentaries Calcium-Binding Proteins - genetics CARD Signaling Adaptor Proteins HIV HIV Infections - complications HIV Infections - drug therapy Humans Inflammation - genetics Lung Prospective Studies South Africa Tuberculosis - genetics
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