A Rh(III)-Catalyzed Formal [4+1] Approach to Pyrrolidines from Unactivated Terminal Alkenes and Nitrene Sources

We have developed a formal [4+1] approach to pyrrolidines from readily available unactivated terminal alkenes as 4-carbon partners. The reaction provides a rapid construction of various pyrrolidine containing structures, especially for the diastereoselective synthesis of spiro-pyrrolidines. Mechanis...

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Veröffentlicht in:	Journal of the American Chemical Society 2019-08, Vol.141 (32), p.12536-12540
Hauptverfasser:	Lee, Sumin, Lei, Honghui, Rovis, Tomislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkenes - chemistry Aziridines - chemical synthesis Catalysis Cycloaddition Reaction Models, Chemical Pyrrolidines - chemical synthesis Rhodium - chemistry
Online-Zugang:	Volltext
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