1-Trifluoromethoxyphenyl-3-(1-Propionylpiperidin-4-yl) Urea Protects the Blood-Brain Barrier Against Ischemic Injury by Upregulating Tight Junction Protein Expression, Mitigating Apoptosis and Inflammation In Vivo and In Vitro Model

We previously have revealed that 1-trifluoromethoxyphenyl-3-(1- propionylpiperidin-4-yl) urea (TPPU), as a soluble epoxide hydrolase (sEH) inhibitor can reduce infarct volume, protect blood-brain barrier (BBB) and brain against ischemic injury in rats. Here, we investigated the potential mechanisms...

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Veröffentlicht in:	Frontiers in pharmacology 2020-08, Vol.11, p.1197-1197
Hauptverfasser:	Yi, Xingyang, Xu, Chongxi, Huang, Pan, Zhang, Linlei, Qing, Ting, Li, Jie, Wang, Chun, Zeng, Tao, Lu, Jing, Han, Zhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Pharmacology
Online-Zugang:	Volltext
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