The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis

Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of intraocular free fatty acids. Free fatty acids may serve as an initiator of inflammatory cytokine release from Müller cells, and the resulting cytokines are potent stimulato...

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Veröffentlicht in:	Experimental eye research 2020-01, Vol.190, p.107885-107885, Article 107885
Hauptverfasser:	Capozzi, Megan E., Savage, Sara R., McCollum, Gary W., Hammer, Sandra S., Ramos, Carla J., Yang, Rong, Bretz, Colin A., Penn, John S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Cells, Cultured Cytokines - metabolism Diabetic retinopathy Endothelial Cells - drug effects Endothelial Cells - metabolism Ependymoglial Cells - drug effects Ependymoglial Cells - metabolism Humans Inflammation Leukostasis - metabolism Leukostasis - prevention & control Male Mice Mice, Inbred C57BL Palmitic Acids - pharmacology Peroxisome proliferator-activated receptors PPAR delta - antagonists & inhibitors PPAR-beta - antagonists & inhibitors Real-Time Polymerase Chain Reaction Retina - drug effects Retina - metabolism Retinitis - metabolism Retinitis - prevention & control Sulfones - pharmacology Thiophenes - pharmacology
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