Developmental trajectory of prehematopoietic stem cell formation from endothelium

Hematopoietic stem and progenitor cells (HSPCs) in the bone marrow are derived from a small population of hemogenic endothelial (HE) cells located in the major arteries of the mammalian embryo. HE cells undergo an endothelial to hematopoietic cell transition, giving rise to HSPCs that accumulate in...

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Veröffentlicht in:	Blood 2020-08, Vol.136 (7), p.845-856
Hauptverfasser:	Zhu, Qin, Gao, Peng, Tober, Joanna, Bennett, Laura, Chen, Changya, Uzun, Yasin, Li, Yan, Howell, Elizabeth D., Mumau, Melanie, Yu, Wenbao, He, Bing, Speck, Nancy A., Tan, Kai
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation - genetics Core Binding Factor Alpha 2 Subunit - physiology Embryo, Mammalian Endothelium - cytology Endothelium - embryology Endothelium - metabolism Female Gene Dosage - physiology Gene Expression Regulation, Developmental Hemangioblasts - cytology Hemangioblasts - physiology Hematopoiesis - genetics Hematopoiesis - physiology Hematopoiesis and Stem Cells Hematopoietic Stem Cells - physiology Male Mice Mice, Inbred C57BL Mice, Transgenic Pregnancy RNA-Seq - methods
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