Histologic evaluation of activation of acute inflammatory response in a mouse model following ultrasound-mediated blood-brain barrier using different acoustic pressures and microbubble doses

Localized blood-brain barrier (BBB) opening can be achieved with minimal to no tissue damage by applying pulsed focused ultrasound alongside a low microbubble (MB) dose. However, relatively little is known regarding how varying treatment parameters affect the degree of neuroinflammation following BB...

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Veröffentlicht in:	Nanotheranostics (Sydney, NSW) NSW), 2020, Vol.4 (4), p.210-223
Hauptverfasser:	Pascal, Aurea, Li, Ningrui, Lechtenberg, Kendra J, Rosenberg, Jarrett, Airan, Raag D, James, Michelle L, Bouley, Donna M, Pauly, Kim Butts
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes - metabolism Blood-Brain Barrier - radiation effects Brain Chemistry - radiation effects Drug Delivery Systems - methods Female Inflammation - metabolism Mice Microbubbles Microglia - metabolism Research Paper Ultrasonic Therapy - methods Ultrasonic Waves
Online-Zugang:	Volltext
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