Toxoplasma infection induces microglia‐neuron contact and the loss of perisomatic inhibitory synapses

Infection and inflammation within the brain induces changes in neuronal connectivity and function. The intracellular protozoan parasite, Toxoplasma gondii, is one pathogen that infects the brain and can cause encephalitis and seizures. Persistent infection by this parasite is also associated with be...

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Veröffentlicht in:	Glia 2020-10, Vol.68 (10), p.1968-1986
Hauptverfasser:	Carrillo, Gabriela L., Ballard, Valerie A., Glausen, Taylor, Boone, Zack, Teamer, Joseph, Hinkson, Cyrus L., Wohlfert, Elizabeth A., Blader, Ira J., Fox, Michael A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Brain Cerebral cortex Chemical synthesis Encephalitis Genetic analysis Glutamate decarboxylase Glutamic acid hippocampus Illnesses Infections inhibitory synapse Mental disorders Microglia Neocortex Nerve endings Neural networks Parasites Parasitic diseases perisomatic synapse Persistent infection Protozoa Scanning electron microscopy Schizophrenia Seizures Synapses Terminals Toxoplasma gondii γ-Aminobutyric acid
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