Xenograft Model for Therapeutic Drug Testing in Recurrent Respiratory Papillomatosis

Objective: Identifying effective treatment for papillomatosis is limited by a lack of animal models, and there is currently no preclinical model for testing potential therapeutic agents. We hypothesized that xenografting of papilloma may facilitate in vivo drug testing to identify novel treatment op...

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Veröffentlicht in:	Annals of otology, rhinology & laryngology rhinology & laryngology, 2015-02, Vol.124 (2), p.110-115
Hauptverfasser:	Ahn, Julie, Bishop, Justin A., Akpeng, Belinda, Pai, Sara I., Best, Simon R.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - pharmacology Animals Antibodies, Monoclonal, Humanized - pharmacology Bevacizumab Drug Evaluation, Preclinical - methods Human papillomavirus 11 - drug effects Human papillomavirus 11 - genetics Humans Mice Mice, Inbred NOD Models, Animal Papilloma - pathology Papilloma - virology Papillomavirus Infections - drug therapy Respiratory Tract Infections - drug therapy Tracheal Neoplasms - pathology Tracheal Neoplasms - virology Transplantation, Heterologous - methods Treatment Outcome
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