Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model
Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains...
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| Veröffentlicht in: | Translational vision science & technology 2020-07, Vol.9 (8), p.44-44 |
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| creator | Braun, Phillip X Mehta, Nihaal Gendelman, Isaac Alibhai, A Yasin Baumal, Caroline R Duker, Jay S Waheed, Nadia K |
| description | Especially since the incorporation of swept laser sources, optical coherence tomography angiography (OCTA) has enabled quantification of choriocapillaris perfusion. A critical step in this process is binarization, which makes angiographic images quantifiable in terms of perfusion metrics. It remains challenging to have confidence that choriocapillaris perfusion metrics reflect the reality of pathophysiologic flow, largely because choice of binarization method can result in significantly different perfusion metric outcomes. This commentary discusses a proof-of-concept case involving comparative assessment of binarization methods for a set of dry age-related macular degeneration OCTA data. One of these methods was deemed preferable based on superior agreement with suspected physiologic and pathophysiologic characteristics, thus demonstrating the principle that, in the absence of gold standards for measurement of choriocapillaris perfusion, the best available approximations of pathophysiology may be used to guide choice of binarization method. |
| doi_str_mv | 10.1167/TVST.9.8.44 |
| format | Article |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Choroid - diagnostic imaging Fluorescein Angiography Geographic Atrophy Humans Perfusion Tomography, Optical Coherence |
| title | Using the Pathophysiology of Dry AMD to Guide Binarization of the Choriocapillaris on OCTA: A Model |
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