Derivatization and combination therapy of current COVID-19 therapeutic agents: a review of mechanistic pathways, adverse effects, and binding sites

[Display omitted] •We summarized the mechanisms of action of 11 repurposed drugs for COVID-19 treatment.•We reviewed clinical trials performed on drugs to treat COVID-19 patients.•We proposed combination therapy using current COVID-19 repurposed drugs.•Repurposed drugs have side effects and could be...

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Veröffentlicht in:	Drug discovery today 2020-10, Vol.25 (10), p.1822-1838
Hauptverfasser:	El Kantar, Sally, Nehmeh, Bilal, Saad, Philippe, Mitri, Gabie, Estephan, Celine, Mroueh, Mohamad, Akoury, Elias, Taleb, Robin I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral Agents - adverse effects Antiviral Agents - therapeutic use Binding Sites Clinical Trials as Topic COVID-19 - metabolism COVID-19 - mortality COVID-19 - virology COVID-19 Drug Treatment Drug Repositioning Drug Therapy, Combination Evidence-Based Medicine Host-Pathogen Interactions Humans Ligands Molecular Targeted Therapy Review SARS-CoV-2 - drug effects SARS-CoV-2 - metabolism SARS-CoV-2 - pathogenicity Signal Transduction - drug effects Treatment Outcome
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