Chromatic Pupilloperimetry Measures Correlate With Visual Acuity and Visual Field Defects in Retinitis Pigmentosa Patients

To evaluate the ability of chromatic pupilloperimetry to identify visual field (VF) defects in patients with retinitis pigmentosa (RP) and to test the correlation between pupilloperimetry impairment and retinal structural and functional measures. The pupil responses of 10 patients with RP (mean age,...

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Veröffentlicht in:Translational vision science & technology 2020-07, Vol.9 (8), p.10-10
Hauptverfasser: Sher, Ifat, Tucker, Yisroel, Gurevich, Maya, Hamburg, Amit, Bubis, Ettel, Kfir, Jonathan, Zorani, Shlomit, Derazne, Estela, Skaat, Alon, Rotenstreich, Ygal
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container_issue 8
container_start_page 10
container_title Translational vision science & technology
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creator Sher, Ifat
Tucker, Yisroel
Gurevich, Maya
Hamburg, Amit
Bubis, Ettel
Kfir, Jonathan
Zorani, Shlomit
Derazne, Estela
Skaat, Alon
Rotenstreich, Ygal
description To evaluate the ability of chromatic pupilloperimetry to identify visual field (VF) defects in patients with retinitis pigmentosa (RP) and to test the correlation between pupilloperimetry impairment and retinal structural and functional measures. The pupil responses of 10 patients with RP (mean age, 41.3 ± 16.2 years) and 32 healthy age-similar controls (mean age, 50.7 ± 15.5 years) for 54 focal blue and red stimuli presented in a 24-2 VF were recorded. The pupilloperimetry measures were correlated with Humphrey VF mean deviation, best-corrected visual acuity, and ellipsoid zone area. Substantially lower percentage of pupil contraction and maximal pupil contraction velocity (MCV) were recorded in patients with RP throughout the VF in response to blue and red stimuli. The mean absolute deviation (MADEV) in the latency of MCV (LMCV) was significantly larger in patients compared with controls for blue and red stimuli ( = 1.0 × 10 and = 1.0 × 10 , respectively). The LMCV MADEV differentiated between patients and controls with high specificity and sensitivity (area under the receiver operating characteristic curve, 0.987 and 0.973 for blue and red, respectively). The MADEV of LMCV for blue stimuli correlated with best-corrected visual acuity (ρ = 0.938, = 5.9 × 10 ) and ellipsoid zone area (ρ = -0.857; = 0.002). The MADEV of LMCV for red stimuli correlated with Humphrey VF mean deviation (ρ = -0.709; = 0.022). Minimizing the test to 15 targets maintained a diagnosis of retinal damage in patients with RP with high sensitivity and specificity (area under the receiver operating characteristic curve, 0.927). The chromatic pupilloperimetry measures significantly correlated with retinal function and structure in patients with RP at various disease stages. Chromatic pupilloperimetry may enable objective assessment of visual field defects and visual acuity in RP.
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The pupil responses of 10 patients with RP (mean age, 41.3 ± 16.2 years) and 32 healthy age-similar controls (mean age, 50.7 ± 15.5 years) for 54 focal blue and red stimuli presented in a 24-2 VF were recorded. The pupilloperimetry measures were correlated with Humphrey VF mean deviation, best-corrected visual acuity, and ellipsoid zone area. Substantially lower percentage of pupil contraction and maximal pupil contraction velocity (MCV) were recorded in patients with RP throughout the VF in response to blue and red stimuli. The mean absolute deviation (MADEV) in the latency of MCV (LMCV) was significantly larger in patients compared with controls for blue and red stimuli ( = 1.0 × 10 and = 1.0 × 10 , respectively). The LMCV MADEV differentiated between patients and controls with high specificity and sensitivity (area under the receiver operating characteristic curve, 0.987 and 0.973 for blue and red, respectively). The MADEV of LMCV for blue stimuli correlated with best-corrected visual acuity (ρ = 0.938, = 5.9 × 10 ) and ellipsoid zone area (ρ = -0.857; = 0.002). The MADEV of LMCV for red stimuli correlated with Humphrey VF mean deviation (ρ = -0.709; = 0.022). Minimizing the test to 15 targets maintained a diagnosis of retinal damage in patients with RP with high sensitivity and specificity (area under the receiver operating characteristic curve, 0.927). The chromatic pupilloperimetry measures significantly correlated with retinal function and structure in patients with RP at various disease stages. 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The MADEV of LMCV for blue stimuli correlated with best-corrected visual acuity (ρ = 0.938, = 5.9 × 10 ) and ellipsoid zone area (ρ = -0.857; = 0.002). The MADEV of LMCV for red stimuli correlated with Humphrey VF mean deviation (ρ = -0.709; = 0.022). Minimizing the test to 15 targets maintained a diagnosis of retinal damage in patients with RP with high sensitivity and specificity (area under the receiver operating characteristic curve, 0.927). The chromatic pupilloperimetry measures significantly correlated with retinal function and structure in patients with RP at various disease stages. 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The pupil responses of 10 patients with RP (mean age, 41.3 ± 16.2 years) and 32 healthy age-similar controls (mean age, 50.7 ± 15.5 years) for 54 focal blue and red stimuli presented in a 24-2 VF were recorded. The pupilloperimetry measures were correlated with Humphrey VF mean deviation, best-corrected visual acuity, and ellipsoid zone area. Substantially lower percentage of pupil contraction and maximal pupil contraction velocity (MCV) were recorded in patients with RP throughout the VF in response to blue and red stimuli. The mean absolute deviation (MADEV) in the latency of MCV (LMCV) was significantly larger in patients compared with controls for blue and red stimuli ( = 1.0 × 10 and = 1.0 × 10 , respectively). The LMCV MADEV differentiated between patients and controls with high specificity and sensitivity (area under the receiver operating characteristic curve, 0.987 and 0.973 for blue and red, respectively). The MADEV of LMCV for blue stimuli correlated with best-corrected visual acuity (ρ = 0.938, = 5.9 × 10 ) and ellipsoid zone area (ρ = -0.857; = 0.002). The MADEV of LMCV for red stimuli correlated with Humphrey VF mean deviation (ρ = -0.709; = 0.022). Minimizing the test to 15 targets maintained a diagnosis of retinal damage in patients with RP with high sensitivity and specificity (area under the receiver operating characteristic curve, 0.927). The chromatic pupilloperimetry measures significantly correlated with retinal function and structure in patients with RP at various disease stages. Chromatic pupilloperimetry may enable objective assessment of visual field defects and visual acuity in RP.</abstract><cop>United States</cop><pub>The Association for Research in Vision and Ophthalmology</pub><pmid>32855857</pmid><doi>10.1167/tvst.9.8.10</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects Adult
Aged
Humans
Middle Aged
Reflex, Pupillary
Retinitis Pigmentosa - diagnosis
Visual Acuity
Visual Field Tests
Visual Fields
title Chromatic Pupilloperimetry Measures Correlate With Visual Acuity and Visual Field Defects in Retinitis Pigmentosa Patients
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