In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure
To identify the factors influencing outcome in childhood mature B-cell non-Hodgkin lymphoma and acute leukemia (B-NHL/AL) with central nervous system (CNS) disease (CNS+), we analyzed patients
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| Veröffentlicht in: | Blood advances 2020-08, Vol.4 (15), p.3621-3625 |
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| creator | Simonin, Mathieu Auperin, Anne Bertrand, Yves Aladjidi, Nathalie Baruchel, André Contet, Audrey Coze, Carole Gandemer, Virginie Haouy, Stephanie Leblanc, Thierry Leverger, Guy Michon, Jean Patte, Catherine Minard-Colin, Veronique |
| description | To identify the factors influencing outcome in childhood mature B-cell non-Hodgkin lymphoma and acute leukemia (B-NHL/AL) with central nervous system (CNS) disease (CNS+), we analyzed patients |
| doi_str_mv | 10.1182/bloodadvances.2019001398 |
| format | Article |
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•Largest cohort of childhood mature B-NHL/AL with CNS disease reporting prevalence, clinical pattern, and outcome.•In patients with CNS disease, those with blasts in the CSF or LDH value above twice the upper normal value are at higher risk of failure.
[Display omitted]</description><identifier>ISSN: 2473-9529</identifier><identifier>EISSN: 2473-9537</identifier><identifier>DOI: 10.1182/bloodadvances.2019001398</identifier><identifier>PMID: 32766852</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Antineoplastic Combined Chemotherapy Protocols ; Central Nervous System Diseases ; Child ; Disease-Free Survival ; Humans ; Lymphoid Neoplasia ; Lymphoma, B-Cell - drug therapy ; Lymphoma, Non-Hodgkin ; Male</subject><ispartof>Blood advances, 2020-08, Vol.4 (15), p.3621-3625</ispartof><rights>2020 American Society of Hematology</rights><rights>2020 by The American Society of Hematology.</rights><rights>2020 by The American Society of Hematology 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-fd90362f7a6801d24b3b744b11d47da7ef1043dc5382d0f9fd6dd4c7712983293</citedby><cites>FETCH-LOGICAL-c479t-fd90362f7a6801d24b3b744b11d47da7ef1043dc5382d0f9fd6dd4c7712983293</cites><orcidid>0000-0002-0296-5207 ; 0000-0003-3996-3835</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422110/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7422110/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32766852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Simonin, Mathieu</creatorcontrib><creatorcontrib>Auperin, Anne</creatorcontrib><creatorcontrib>Bertrand, Yves</creatorcontrib><creatorcontrib>Aladjidi, Nathalie</creatorcontrib><creatorcontrib>Baruchel, André</creatorcontrib><creatorcontrib>Contet, Audrey</creatorcontrib><creatorcontrib>Coze, Carole</creatorcontrib><creatorcontrib>Gandemer, Virginie</creatorcontrib><creatorcontrib>Haouy, Stephanie</creatorcontrib><creatorcontrib>Leblanc, Thierry</creatorcontrib><creatorcontrib>Leverger, Guy</creatorcontrib><creatorcontrib>Michon, Jean</creatorcontrib><creatorcontrib>Patte, Catherine</creatorcontrib><creatorcontrib>Minard-Colin, Veronique</creatorcontrib><title>In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure</title><title>Blood advances</title><addtitle>Blood Adv</addtitle><description>To identify the factors influencing outcome in childhood mature B-cell non-Hodgkin lymphoma and acute leukemia (B-NHL/AL) with central nervous system (CNS) disease (CNS+), we analyzed patients <18 years with newly diagnosed B-NHL/AL registered in 3 Lymphomes Malins B studies in France between 1989 to 2011. CNS+ was diagnosed on fulfillment of ≥1 of the following criteria: any L3 cerebrospinal fluid (CSF) blasts (CSF+), cranial nerve palsy, isolated intracerebral mass but also clinical spinal cord compression, and cranial or spinal parameningeal extension. Two hundred seventeen out of 1690 patients (12.8%) were CNS+. CNS+ was significantly associated with male gender, head/neck locations, Burkitt histology, high initial lactate dehydrogenase (LDH) level, and bone marrow involvement. CSF+ was the most frequent pattern of CNS+ (45%). For the 217 CNS+ patients, the 5-year event-free survival (EFS) and overall survival rates (95% confidence interval) were 81.5% (75.8% to 86.1%) and 83.9% (78.4% to 88.2%), respectively. In multivariate analysis, among CNS+ patients, low EFS was associated with CSF+, high initial LDH level, and poor response to cyclophosphamide, oncovin (vincristine), prednisone prephase. These findings have been considered for patient's stratification in the international randomized phase 3 trial Inter-B-NHL-ritux 2010 for children and adolescents with high-risk B-NHL/AL with CNS+ CSF+ patients only receiving intensified chemotherapy.
•Largest cohort of childhood mature B-NHL/AL with CNS disease reporting prevalence, clinical pattern, and outcome.•In patients with CNS disease, those with blasts in the CSF or LDH value above twice the upper normal value are at higher risk of failure.
[Display omitted]</description><subject>Adolescent</subject><subject>Antineoplastic Combined Chemotherapy Protocols</subject><subject>Central Nervous System Diseases</subject><subject>Child</subject><subject>Disease-Free Survival</subject><subject>Humans</subject><subject>Lymphoid Neoplasia</subject><subject>Lymphoma, B-Cell - drug therapy</subject><subject>Lymphoma, Non-Hodgkin</subject><subject>Male</subject><issn>2473-9529</issn><issn>2473-9537</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQxS0EolXpV0A-cmBT_8t6fUGiUWkrReUAnC2vPe4anHWwd1Px7esqbdqeOM1I8-b3RvMQwpQsKO3YWR9TcsbtzGihLBihihDKVfcGHTMheaOWXL499EwdodNSfpMqki1fKvYeHXEm27ZbsmM0X4_YDiG6oULxxkxzBnze3Fyt8V2YBry6-YFdKGAKfMZbMwUYp7If9dGU2ocKgAx9TmUbRhOxj3Nw2FSOmfAQbgfIOIfyByePvQmxOnxA77yJBU4f6wn69e3i5-qqWX-_vF59XTdWSDU13inCW-alaTtCHRM976UQPaVOSGckeEoEd3bJO-aIV961zgkrJWWq40zxE_Rlz93O_QacrcdnE_U2h43J_3QyQb-ejGHQt2mnpWCMUlIBnx4BOf2doUx6E4qFGM0IaS6aCU47Kpl6kHZ7qa2fKBn8wYYS_RCcfhWcfg6urn58eeZh8SmmKjjfC6A-axcg62JrEhZcyGAn7VL4v8s97GCwfA</recordid><startdate>20200811</startdate><enddate>20200811</enddate><creator>Simonin, Mathieu</creator><creator>Auperin, Anne</creator><creator>Bertrand, Yves</creator><creator>Aladjidi, Nathalie</creator><creator>Baruchel, André</creator><creator>Contet, Audrey</creator><creator>Coze, Carole</creator><creator>Gandemer, Virginie</creator><creator>Haouy, Stephanie</creator><creator>Leblanc, Thierry</creator><creator>Leverger, Guy</creator><creator>Michon, Jean</creator><creator>Patte, Catherine</creator><creator>Minard-Colin, Veronique</creator><general>Elsevier Inc</general><general>American Society of Hematology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0296-5207</orcidid><orcidid>https://orcid.org/0000-0003-3996-3835</orcidid></search><sort><creationdate>20200811</creationdate><title>In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure</title><author>Simonin, Mathieu ; Auperin, Anne ; Bertrand, Yves ; Aladjidi, Nathalie ; Baruchel, André ; Contet, Audrey ; Coze, Carole ; Gandemer, Virginie ; Haouy, Stephanie ; Leblanc, Thierry ; Leverger, Guy ; Michon, Jean ; Patte, Catherine ; Minard-Colin, Veronique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-fd90362f7a6801d24b3b744b11d47da7ef1043dc5382d0f9fd6dd4c7712983293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Antineoplastic Combined Chemotherapy Protocols</topic><topic>Central Nervous System Diseases</topic><topic>Child</topic><topic>Disease-Free Survival</topic><topic>Humans</topic><topic>Lymphoid Neoplasia</topic><topic>Lymphoma, B-Cell - drug therapy</topic><topic>Lymphoma, Non-Hodgkin</topic><topic>Male</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Simonin, Mathieu</creatorcontrib><creatorcontrib>Auperin, Anne</creatorcontrib><creatorcontrib>Bertrand, Yves</creatorcontrib><creatorcontrib>Aladjidi, Nathalie</creatorcontrib><creatorcontrib>Baruchel, André</creatorcontrib><creatorcontrib>Contet, Audrey</creatorcontrib><creatorcontrib>Coze, Carole</creatorcontrib><creatorcontrib>Gandemer, Virginie</creatorcontrib><creatorcontrib>Haouy, Stephanie</creatorcontrib><creatorcontrib>Leblanc, Thierry</creatorcontrib><creatorcontrib>Leverger, Guy</creatorcontrib><creatorcontrib>Michon, Jean</creatorcontrib><creatorcontrib>Patte, Catherine</creatorcontrib><creatorcontrib>Minard-Colin, Veronique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Blood advances</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Simonin, Mathieu</au><au>Auperin, Anne</au><au>Bertrand, Yves</au><au>Aladjidi, Nathalie</au><au>Baruchel, André</au><au>Contet, Audrey</au><au>Coze, Carole</au><au>Gandemer, Virginie</au><au>Haouy, Stephanie</au><au>Leblanc, Thierry</au><au>Leverger, Guy</au><au>Michon, Jean</au><au>Patte, Catherine</au><au>Minard-Colin, Veronique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure</atitle><jtitle>Blood advances</jtitle><addtitle>Blood Adv</addtitle><date>2020-08-11</date><risdate>2020</risdate><volume>4</volume><issue>15</issue><spage>3621</spage><epage>3625</epage><pages>3621-3625</pages><issn>2473-9529</issn><eissn>2473-9537</eissn><abstract>To identify the factors influencing outcome in childhood mature B-cell non-Hodgkin lymphoma and acute leukemia (B-NHL/AL) with central nervous system (CNS) disease (CNS+), we analyzed patients <18 years with newly diagnosed B-NHL/AL registered in 3 Lymphomes Malins B studies in France between 1989 to 2011. CNS+ was diagnosed on fulfillment of ≥1 of the following criteria: any L3 cerebrospinal fluid (CSF) blasts (CSF+), cranial nerve palsy, isolated intracerebral mass but also clinical spinal cord compression, and cranial or spinal parameningeal extension. Two hundred seventeen out of 1690 patients (12.8%) were CNS+. CNS+ was significantly associated with male gender, head/neck locations, Burkitt histology, high initial lactate dehydrogenase (LDH) level, and bone marrow involvement. CSF+ was the most frequent pattern of CNS+ (45%). For the 217 CNS+ patients, the 5-year event-free survival (EFS) and overall survival rates (95% confidence interval) were 81.5% (75.8% to 86.1%) and 83.9% (78.4% to 88.2%), respectively. In multivariate analysis, among CNS+ patients, low EFS was associated with CSF+, high initial LDH level, and poor response to cyclophosphamide, oncovin (vincristine), prednisone prephase. These findings have been considered for patient's stratification in the international randomized phase 3 trial Inter-B-NHL-ritux 2010 for children and adolescents with high-risk B-NHL/AL with CNS+ CSF+ patients only receiving intensified chemotherapy.
•Largest cohort of childhood mature B-NHL/AL with CNS disease reporting prevalence, clinical pattern, and outcome.•In patients with CNS disease, those with blasts in the CSF or LDH value above twice the upper normal value are at higher risk of failure.
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adolescent Antineoplastic Combined Chemotherapy Protocols Central Nervous System Diseases Child Disease-Free Survival Humans Lymphoid Neoplasia Lymphoma, B-Cell - drug therapy Lymphoma, Non-Hodgkin Male |
| title | In childhood mature B-NHL with CNS disease, patients with blasts in cerebrospinal fluid are at higher risk of failure |
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