Overcoming Genetically Based Resistance Mechanisms to PD-1 Blockade

Mechanism-based strategies to overcome resistance to PD-1 blockade therapy are urgently needed. We developed genetic acquired resistant models of , and loss-of-function mutations by gene knockout in human and murine cell lines. Human melanoma cell lines with knockout became insensitive to IFN-induce...

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Veröffentlicht in:	Cancer discovery 2020-08, Vol.10 (8), p.1140-1157
Hauptverfasser:	Torrejon, Davis Y, Abril-Rodriguez, Gabriel, Champhekar, Ameya S, Tsoi, Jennifer, Campbell, Katie M, Kalbasi, Anusha, Parisi, Giulia, Zaretsky, Jesse M, Garcia-Diaz, Angel, Puig-Saus, Cristina, Cheung-Lau, Gardenia, Wohlwender, Thomas, Krystofinski, Paige, Vega-Crespo, Agustin, Lee, Christopher M, Mascaro, Pau, Grasso, Catherine S, Berent-Maoz, Beata, Comin-Anduix, Begoña, Hu-Lieskovan, Siwen, Ribas, Antoni
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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