Drug repurposing for targeting cyclic nucleotide transporters in acute leukemias - A missed opportunity

While current treatment regimens for acute leukemia can dramatically improve patient survival, there remains room for improvement. Due to its roles in cell differentiation, cell survival, and apoptotic signaling, modulation of the cyclic AMP (cAMP) pathway has provided a meaningful target in hematol...

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Veröffentlicht in:	Seminars in cancer biology 2021-01, Vol.68, p.199-208
Hauptverfasser:	Perez, Dominique R., Sklar, Larry A., Chigaev, Alexandre, Matlawska-Wasowska, Ksenia
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-cyclic adenosine monophosphate (cAMP) Acute lymphoblastic leukemia (ALL) Acute myelogenous leukemia (AML) Animals Antineoplastic Agents - therapeutic use ATP-binding cassette (ABC) transporters ATP-Binding Cassette Transporters - antagonists & inhibitors Cyclic AMP - metabolism Cyclic GMP - metabolism Drug Discovery Drug Repositioning - methods Efflux Humans Inhibitors of cAMP efflux (ICE) Leukemia - drug therapy
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