HSV-1 Hijacks the Host DNA Damage Response in Corneal Epithelial Cells through ICP4-Mediated Activation of ATM

Herpes simplex virus type I (HSV-1) infection of corneal epithelial cells activates ataxia telangiectasia mutated (ATM), an apical kinase in the host DNA damage response pathway, whose activity is necessary for the progression of lytic HSV-1 infection. The purpose of this study is to investigate the...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2020-06, Vol.61 (6), p.39-39
Hauptverfasser:	Alekseev, Oleg, Donegan, William E, Donovan, Kelly R, Limonnik, Vladimir, Azizkhan-Clifford, Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured DNA Damage DNA Replication DNA, Viral - genetics Epithelium, Corneal - metabolism Epithelium, Corneal - pathology Epithelium, Corneal - virology Eye Infections, Viral - metabolism Eye Infections, Viral - pathology Eye Infections, Viral - virology Herpesvirus 1, Human - genetics Humans Immunology and Microbiology Keratitis, Herpetic - metabolism Keratitis, Herpetic - pathology Keratitis, Herpetic - virology Virus Replication - physiology
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