Endothelial injury and thrombotic microangiopathy in COVID-19: Treatment with the lectin-pathway inhibitor narsoplimab

•Narsoplimab down-modulates SARS-CoV-2-induced activation of the lectin pathway and endothelial cell damage.•Narsoplimab can reduce the thrombotic risk of Covid-19 patients.•All patients treated with narsoplimab improved and survived without any drug-related adverse events. In COVID-19, acute respir...

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Veröffentlicht in:	Immunobiology (1979) 2020-11, Vol.225 (6), p.152001-152001, Article 152001
Hauptverfasser:	Rambaldi, Alessandro, Gritti, Giuseppe, Micò, Maria Caterina, Frigeni, Marco, Borleri, Gianmaria, Salvi, Anna, Landi, Francesco, Pavoni, Chiara, Sonzogni, Aurelio, Gianatti, Andrea, Binda, Francesca, Fagiuoli, Stefano, Di Marco, Fabiano, Lorini, Luca, Remuzzi, Giuseppe, Whitaker, Steve, Demopulos, Gregory
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - therapeutic use C-Reactive Protein - immunology C-Reactive Protein - metabolism Complement Pathway, Mannose-Binding Lectin - drug effects Complement Pathway, Mannose-Binding Lectin - immunology COVID-19 COVID-19 - complications COVID-19 - immunology COVID-19 - virology Endothelial injury Endothelium, Vascular - drug effects Endothelium, Vascular - immunology Endothelium, Vascular - pathology Female Humans Immunoglobulin G - immunology Immunoglobulin G - therapeutic use Inflammation - complications Inflammation - immunology Inflammation - prevention & control Interleukin-6 - blood Interleukin-6 - immunology Lectin pathway Male Mannose-Binding Protein-Associated Serine Proteases - antagonists & inhibitors Mannose-Binding Protein-Associated Serine Proteases - immunology Mannose-Binding Protein-Associated Serine Proteases - metabolism MASP-2 Middle Aged Monoclonal antibody Narsoplimab Outcome Assessment, Health Care - methods Outcome Assessment, Health Care - statistics & numerical data Retrospective Studies SARS-CoV-2 SARS-CoV-2 - immunology SARS-CoV-2 - physiology Thrombosis Thrombotic Microangiopathies - complications Thrombotic Microangiopathies - drug therapy Thrombotic Microangiopathies - immunology
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