Network-based modeling of drug effects on disease module in systemic sclerosis

The network-based proximity between drug targets and disease genes can provide novel insights regarding the repercussions, interplay, and repositioning of drugs in the context of disease. Current understanding and treatment for reversing of the fibrotic process is limited in systemic sclerosis (SSc)...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.13393-13393, Article 13393
Hauptverfasser:	Kim, Ki-Jo, Moon, Su-Jin, Park, Kyung-Su, Tagkopoulos, Ilias
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114 631/553 692/4023 Acetylcysteine Acetylcysteine - pharmacology Acetylcysteine - therapeutic use Dasatinib - pharmacology Dasatinib - therapeutic use Drug development Drug Repositioning Female Fibrosis Fibrosis - genetics Fibrosis - pathology Gene expression Genome-Wide Association Study Genomes Humanities and Social Sciences Humans Imatinib Imatinib Mesylate - pharmacology Imatinib Mesylate - therapeutic use Indoles - pharmacology Indoles - therapeutic use Inflammation Kinases Male Molecular Targeted Therapy multidisciplinary Pathophysiology Protein Kinase Inhibitors - pharmacology Protein Kinase Inhibitors - therapeutic use Protein-tyrosine kinase Science Science (multidisciplinary) Scleroderma Scleroderma, Systemic - drug therapy Scleroderma, Systemic - genetics Scleroderma, Systemic - pathology Signal Transduction - drug effects Systemic sclerosis Therapeutic targets
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