Genetic heterogeneity and prognostic impact of recurrent ANK2 and TP53 mutations in mantle cell lymphoma: a multi-centre cohort study

The molecular features of mantle cell lymphoma (MCL), including its increased incidence, and complex therapies have not been investigated in detail, particularly in East Asian populations. In this study, we performed targeted panel sequencing (TPS) and whole-exome sequencing (WES) to investigate the...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.13359-13359, Article 13359
Hauptverfasser:	Jeong, Seri, Park, Yu Jin, Yun, Woobin, Lee, Seung-Tae, Choi, Jong Rak, Suh, Cheolwon, Jo, Jae-Cheol, Cha, Hee Jeong, Jeong, Jee-Yeong, Chang, HeeKyung, Cha, Yoon Jin, Kim, Hyerim, Park, Min-Jeong, Song, Wonkeun, Cho, Eun-Hae, Jeong, Eun-Goo, Lee, Junnam, Park, Yongmin, Lee, Yong Seok, Kim, Da Jung, Lee, Ho Sup
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/1990 631/67/68 692/4017 Aged Ankyrins - genetics Apoptosis Cell cycle Cell death Cohort analysis Female Gene expression Genetic Heterogeneity Genetic Predisposition to Disease - genetics Heterogeneity Humanities and Social Sciences Humans Kaplan-Meier Estimate Lymphoma Lymphoma, Mantle-Cell - diagnosis Lymphoma, Mantle-Cell - genetics Lymphoma, Mantle-Cell - mortality Male Mantle cell lymphoma Middle Aged multidisciplinary Multivariate analysis Mutation Mutation - genetics p53 Protein Population studies Prognosis Progression-Free Survival Republic of Korea - epidemiology Science Science (multidisciplinary) Survival Analysis Tumor Suppressor Protein p53 - genetics Whole Genome Sequencing
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