Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program
To compare the clinicopathological characteristics and survival outcomes of children and adult diagnosed with medullary thyroid carcinoma (MTC). MTC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 to 2016, followed by stratification into pediatri...
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| creator | Zhao, Zhuang Yin, Xiang-dang Zhang, Xu-he Li, Zhi-wen Wang, Dun-wei |
| description | To compare the clinicopathological characteristics and survival outcomes of children and adult diagnosed with medullary thyroid carcinoma (MTC). MTC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 to 2016, followed by stratification into pediatric ( |
| doi_str_mv | 10.1038/s41598-020-70439-7 |
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P
< 0.001). Multivariable Cox regression analysis revealed that adult patients were significantly correlated with worse CSS and OS rates [(CSS: HR 11.60, 95% CI 1.62–83.02,
P
= 0.015); (OS: HR 5.63, 95% CI 2.08–15.25,
P
= 0.001)]. Further stratified analysis indicated that pediatric group might have significant better CSS and OS for patients with more advanced stage. Patients in the pediatric group were more likely to have earlier stage. Moreover, the prognosis of pediatric MTC patients was significantly better than that in adult patients.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-70439-7</identifier><identifier>PMID: 32764626</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/67 ; 692/4028 ; 692/499 ; Adolescent ; Adult ; Carcinoma, Neuroendocrine - diagnosis ; Carcinoma, Neuroendocrine - epidemiology ; Carcinoma, Neuroendocrine - pathology ; Carcinoma, Neuroendocrine - therapy ; Child ; Child, Preschool ; Epidemiology ; Female ; Humanities and Social Sciences ; Humans ; Male ; Medical prognosis ; multidisciplinary ; Multivariate Analysis ; Patients ; Pediatrics ; Regression analysis ; Science ; Science (multidisciplinary) ; SEER Program ; Surgery ; Survival Analysis ; Thyroid ; Thyroid cancer ; Thyroid carcinoma ; Thyroid Neoplasms - diagnosis ; Thyroid Neoplasms - epidemiology ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - therapy ; Thyroidectomy ; Young Adult</subject><ispartof>Scientific reports, 2020-08, Vol.10 (1), p.13310-13310, Article 13310</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c540t-9eede41eb58affa34dd7419be8a1101ddb7b02afa392980aa50478c3a194af963</citedby><cites>FETCH-LOGICAL-c540t-9eede41eb58affa34dd7419be8a1101ddb7b02afa392980aa50478c3a194af963</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413344/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413344/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32764626$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhao, Zhuang</creatorcontrib><creatorcontrib>Yin, Xiang-dang</creatorcontrib><creatorcontrib>Zhang, Xu-he</creatorcontrib><creatorcontrib>Li, Zhi-wen</creatorcontrib><creatorcontrib>Wang, Dun-wei</creatorcontrib><title>Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>To compare the clinicopathological characteristics and survival outcomes of children and adult diagnosed with medullary thyroid carcinoma (MTC). MTC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 to 2016, followed by stratification into pediatric (< 20 years) or adult (≥ 20 years) groups. In total, 2,197 patients (110 pediatric and 2087 adult) with MTC were identified. Pediatric patients were more likely to have localized stage (70.0% vs. 51.6%), negative regional nodes (48.2% vs. 30.8%) and receive total/subtotal thyroidectomy surgery (97.3% vs. 85.3%). Moreover, CSS and OS rates were significantly higher in pediatric patients (both
P
< 0.001). Multivariable Cox regression analysis revealed that adult patients were significantly correlated with worse CSS and OS rates [(CSS: HR 11.60, 95% CI 1.62–83.02,
P
= 0.015); (OS: HR 5.63, 95% CI 2.08–15.25,
P
= 0.001)]. Further stratified analysis indicated that pediatric group might have significant better CSS and OS for patients with more advanced stage. Patients in the pediatric group were more likely to have earlier stage. Moreover, the prognosis of pediatric MTC patients was significantly better than that in adult patients.</description><subject>631/67</subject><subject>692/4028</subject><subject>692/499</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Carcinoma, Neuroendocrine - diagnosis</subject><subject>Carcinoma, Neuroendocrine - epidemiology</subject><subject>Carcinoma, Neuroendocrine - pathology</subject><subject>Carcinoma, Neuroendocrine - therapy</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>multidisciplinary</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Regression analysis</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>SEER Program</subject><subject>Surgery</subject><subject>Survival Analysis</subject><subject>Thyroid</subject><subject>Thyroid cancer</subject><subject>Thyroid carcinoma</subject><subject>Thyroid Neoplasms - 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diagnosis</topic><topic>Carcinoma, Neuroendocrine - epidemiology</topic><topic>Carcinoma, Neuroendocrine - pathology</topic><topic>Carcinoma, Neuroendocrine - therapy</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Male</topic><topic>Medical prognosis</topic><topic>multidisciplinary</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Regression analysis</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>SEER Program</topic><topic>Surgery</topic><topic>Survival Analysis</topic><topic>Thyroid</topic><topic>Thyroid cancer</topic><topic>Thyroid carcinoma</topic><topic>Thyroid Neoplasms - diagnosis</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - therapy</topic><topic>Thyroidectomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Zhuang</creatorcontrib><creatorcontrib>Yin, Xiang-dang</creatorcontrib><creatorcontrib>Zhang, Xu-he</creatorcontrib><creatorcontrib>Li, Zhi-wen</creatorcontrib><creatorcontrib>Wang, Dun-wei</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Zhuang</au><au>Yin, Xiang-dang</au><au>Zhang, Xu-he</au><au>Li, Zhi-wen</au><au>Wang, Dun-wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-08-06</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>13310</spage><epage>13310</epage><pages>13310-13310</pages><artnum>13310</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>To compare the clinicopathological characteristics and survival outcomes of children and adult diagnosed with medullary thyroid carcinoma (MTC). MTC patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1998 to 2016, followed by stratification into pediatric (< 20 years) or adult (≥ 20 years) groups. In total, 2,197 patients (110 pediatric and 2087 adult) with MTC were identified. Pediatric patients were more likely to have localized stage (70.0% vs. 51.6%), negative regional nodes (48.2% vs. 30.8%) and receive total/subtotal thyroidectomy surgery (97.3% vs. 85.3%). Moreover, CSS and OS rates were significantly higher in pediatric patients (both
P
< 0.001). Multivariable Cox regression analysis revealed that adult patients were significantly correlated with worse CSS and OS rates [(CSS: HR 11.60, 95% CI 1.62–83.02,
P
= 0.015); (OS: HR 5.63, 95% CI 2.08–15.25,
P
= 0.001)]. Further stratified analysis indicated that pediatric group might have significant better CSS and OS for patients with more advanced stage. Patients in the pediatric group were more likely to have earlier stage. Moreover, the prognosis of pediatric MTC patients was significantly better than that in adult patients.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32764626</pmid><doi>10.1038/s41598-020-70439-7</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/67 692/4028 692/499 Adolescent Adult Carcinoma, Neuroendocrine - diagnosis Carcinoma, Neuroendocrine - epidemiology Carcinoma, Neuroendocrine - pathology Carcinoma, Neuroendocrine - therapy Child Child, Preschool Epidemiology Female Humanities and Social Sciences Humans Male Medical prognosis multidisciplinary Multivariate Analysis Patients Pediatrics Regression analysis Science Science (multidisciplinary) SEER Program Surgery Survival Analysis Thyroid Thyroid cancer Thyroid carcinoma Thyroid Neoplasms - diagnosis Thyroid Neoplasms - epidemiology Thyroid Neoplasms - pathology Thyroid Neoplasms - therapy Thyroidectomy Young Adult |
| title | Comparison of pediatric and adult medullary thyroid carcinoma based on SEER program |
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