Ablation of Gadd45β ameliorates the inflammation and renal fibrosis caused by unilateral ureteral obstruction

The growth arrest and DNA damage‐inducible beta (Gadd45β) protein have been associated with various cellular functions, but its role in progressive renal disease is currently unknown. Here, we examined the effect of Gadd45β deletion on cell proliferation and apoptosis, inflammation, and renal fibros...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of cellular and molecular medicine 2020-08, Vol.24 (15), p.8814-8825
Hauptverfasser:	Moon, Sung‐Je, Kim, Jae‐Hoon, Choi, Young‐Keun, Lee, Chul‐Ho, Hwang, Jung Hwan
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Animals Antibodies Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Apoptosis Apoptosis - genetics Biomarkers Biopsy Bone marrow Cell cycle Cell growth Cell Line Cell Proliferation chronic kidney disease Clonal deletion Cytokines Cytokines - metabolism Disease Models, Animal Disease Susceptibility DNA damage Fibroblasts Fibrosis Gene Deletion Genes Genotypes Immunohistochemistry Inflammation Inflammation Mediators Kidney diseases Kidney Diseases - etiology Kidney Diseases - metabolism Kidney Diseases - pathology Kinases Laboratories Lipopolysaccharides Macrophages Male Mice Mice, Knockout Original Penicillin renal fibrosis Renal Insufficiency, Chronic - etiology Renal Insufficiency, Chronic - metabolism Renal Insufficiency, Chronic - pathology Signal transduction TGF‐β signalling Transforming Growth Factor beta - metabolism unilateral ureteral obstruction Ureteral Obstruction - complications
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!