Transglutaminase-2 regulates Wnt and FoxO3a signaling to determine the severity of osteoarthritis

Transglutaminase 2 (TG2), also known as tissue transglutaminase, is a calcium-dependent enzyme that has a variety of intracellular and extracellular substrates. TG2 not only increases in osteoarthritis (OA) tissue but also affects the progression of OA. However, it is still unclear how TG2 affects c...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.13228-13228, Article 13228
Hauptverfasser:	Han, Min-Su, Jung, Youn-Kwan, Kim, Gun-Woo, Han, Seungwoo
Format:	Artikel
Sprache:	eng
Schlagworte:	692/4017 692/4023/1670/407 692/4023/1671/1354 Animals Arthritis beta Catenin - metabolism Calcium Calcium - metabolism Calcium ionophores Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - metabolism Cbfa-1 protein Cells, Cultured Chondrocytes Collagenase 3 Enzymatic activity Forkhead Box Protein O3 - metabolism FOXO3 protein Growth plate Growth Plate - metabolism GTP-Binding Proteins - antagonists & inhibitors GTP-Binding Proteins - metabolism Humanities and Social Sciences Male Matrix Metalloproteinase 13 - metabolism Matrix Metalloproteinase 3 - metabolism Mice Mice, Inbred C57BL multidisciplinary NF-kappa B - metabolism Nuclear transport Osteoarthritis Osteoarthritis - metabolism Osteoarthritis - physiopathology Patient Acuity Peptides Phosphorylation Proteasomes Protein Glutamine gamma Glutamyltransferase 2 Science Science (multidisciplinary) Transforming Growth Factor beta - metabolism Transforming growth factor-b1 Transglutaminase 2 Transglutaminases - antagonists & inhibitors Transglutaminases - metabolism Translocation Ubiquitination Wnt protein Wnt Signaling Pathway β-Catenin
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