Prevalence of CYP2D6 Genotypes and Predicted Phenotypes in a Cohort of Cambodians at High Risk for Infections with Plasmodium vivax

Clinical failure of primaquine (PQ) has been demonstrated in people with CYP450 2D6 genetic polymorphisms that result in reduced or no enzyme activity. The distribution of CYP2D6 genotypes and predicted phenotypes in the Cambodian population is not well described. Surveys in other Asian countries ha...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The American journal of tropical medicine and hygiene 2020-08, Vol.103 (2), p.756-759
Hauptverfasser:	Spring, Michele D, Lon, Chanthap, Sok, Somethy, Sea, Darapiseth, Wojnarski, Mariusz, Chann, Soklyda, Kuntawunginn, Worachet, Kheang Heng, Thay, Nou, Samon, Arsanok, Montri, Sriwichai, Sabaithip, Vanachayangkul, Pattaraporn, Lin, Jessica T, Manning, Jessica E, Jongsakul, Krisada, Pichyangkul, Sathit, Satharath, Prom, Smith, Philip L, Dysoley, Lek, Saunders, David L, Waters, Norman C
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimalarials - therapeutic use Artemisinins - therapeutic use Asians - genetics Cambodia Cytochrome P-450 CYP2D6 - genetics Drug Therapy, Combination Endemic Diseases Gene Frequency Genotype Genotype & phenotype Humans Malaria, Vivax - drug therapy Parasites Parasitic diseases Pharmacogenomic Variants Phenotype Plasmodium vivax Polymorphism, Genetic Primaquine - therapeutic use Quinolines - therapeutic use Recurrence Risk factors Treatment Failure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!