Chronic Administration of the N -Methyl-D-Aspartate Receptor Antagonist Ketamine Improves Rett Syndrome Phenotype

Abstract Background Rett syndrome (RTT) is a neurological disorder caused by mutation of the X-linked MECP2 gene, which results in the progressive disruption of excitatory and inhibitory neuronal circuits. To date, there is no effective treatment available for the disorder. Studies conducted in RTT...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biological psychiatry (1969) 2016-05, Vol.79 (9), p.755-764
Hauptverfasser:	Patrizi, Annarita, Picard, Nathalie, Simon, Alex Joseph, Gunner, Georgia, Centofante, Eleonora, Andrews, Nick Arthur, Fagiolini, Michela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Breathing Cortical activity Disease Models, Animal GABAergic Neurons - drug effects GABAergic Neurons - metabolism Ketamine - administration & dosage Ketamine - pharmacokinetics Ketamine - therapeutic use Methyl-CpG-Binding Protein 2 - genetics Mice Mice, Inbred C57BL Mice, Knockout Neurons - drug effects Neurons - physiology Parvalbumin connectivity Parvalbumins - metabolism Phenotype Photic Stimulation Preclinical trial Psychiatry Pyramidal Cells - drug effects Pyramidal Cells - metabolism Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Respiration - drug effects Rett Syndrome - drug therapy Rett Syndrome - physiopathology Survival Survival Analysis Visual Acuity - drug effects Visual Cortex - drug effects Visual Cortex - physiopathology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!