Taste-related reward is associated with weight loss following bariatric surgery
BACKGROUNDBariatric surgeries are the most effective treatments for successful and sustained weight loss, but individuals vary in treatment response. Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic ap...
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| Veröffentlicht in: | The Journal of clinical investigation 2020-08, Vol.130 (8), p.4370-4381 |
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| creator | Smith, Kimberly R Papantoni, Afroditi Veldhuizen, Maria G Kamath, Vidyulata Harris, Civonnia Moran, Timothy H Carnell, Susan Steele, Kimberley E |
| description | BACKGROUNDBariatric surgeries are the most effective treatments for successful and sustained weight loss, but individuals vary in treatment response. Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic approaches and improve treatment outcomes. The primary objectives of this study were to investigate changes in taste preferences and taste-induced brain responses after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) and to identify potential taste-related predictors of weight loss.METHODSFemales, ages 18 to 55, with a body mass index greater than or equal to 35 kg/m2, and approved for bariatric surgery at the Johns Hopkins Center for Bariatric Surgery were recruited for participation. Demographics, anthropometrics, liking ratings, and neural responses to varying concentrations of sucrose plus fat mixtures were assessed before and after surgery via visual analog scales and functional MRI.RESULTSBariatric surgery produced decreases in liking for sucrose-sweetened mixtures. Greater preference for sucrose-sweetened mixtures before surgery was associated with greater weight loss in RYGB, but not VSG. In the RYGB group only, individuals who showed lower taste-induced activation in the ventral tegmental area (VTA) before surgery and greater changes in taste-induced VTA activation 2 weeks following surgery experienced increased weight loss.CONCLUSIONThe anatomical and/or metabolic changes associated with RYGB may more effectively "reset" the neural processing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in patients with obesity. Further, these findings suggest that RYGB may be particularly effective in patients with a preference for sweet foods.FUNDINGNIH K23DK100559 and Dalio Philanthropies. |
| doi_str_mv | 10.1172/JCI137772 |
| format | Article |
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Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic approaches and improve treatment outcomes. The primary objectives of this study were to investigate changes in taste preferences and taste-induced brain responses after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) and to identify potential taste-related predictors of weight loss.METHODSFemales, ages 18 to 55, with a body mass index greater than or equal to 35 kg/m2, and approved for bariatric surgery at the Johns Hopkins Center for Bariatric Surgery were recruited for participation. Demographics, anthropometrics, liking ratings, and neural responses to varying concentrations of sucrose plus fat mixtures were assessed before and after surgery via visual analog scales and functional MRI.RESULTSBariatric surgery produced decreases in liking for sucrose-sweetened mixtures. Greater preference for sucrose-sweetened mixtures before surgery was associated with greater weight loss in RYGB, but not VSG. In the RYGB group only, individuals who showed lower taste-induced activation in the ventral tegmental area (VTA) before surgery and greater changes in taste-induced VTA activation 2 weeks following surgery experienced increased weight loss.CONCLUSIONThe anatomical and/or metabolic changes associated with RYGB may more effectively "reset" the neural processing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in patients with obesity. Further, these findings suggest that RYGB may be particularly effective in patients with a preference for sweet foods.FUNDINGNIH K23DK100559 and Dalio Philanthropies.</description><identifier>ISSN: 0021-9738</identifier><identifier>EISSN: 1558-8238</identifier><identifier>DOI: 10.1172/JCI137772</identifier><identifier>PMID: 32427584</identifier><language>eng</language><publisher>United States: American Society for Clinical Investigation</publisher><subject>Adolescent ; Adult ; Bariatric surgery ; Biomedical research ; Body mass index ; Body weight loss ; Care and treatment ; Clinical Medicine ; Demographics ; Demography ; Dopamine ; Female ; Food ; Food preferences ; Functional magnetic resonance imaging ; Gastrectomy ; Gastric Bypass ; Gastroesophageal reflux ; Gastrointestinal surgery ; Health aspects ; Humans ; Information processing ; Mesolimbic system ; Middle Aged ; Obesity ; Obesity - physiopathology ; Obesity - surgery ; Patients ; Preferences ; Ratings & rankings ; Reinforcement ; Sucrose ; Surgery ; Sweet taste ; Taste ; Taste preferences ; Ventral tegmentum ; Weight control ; Weight Loss ; Weight loss maintenance</subject><ispartof>The Journal of clinical investigation, 2020-08, Vol.130 (8), p.4370-4381</ispartof><rights>COPYRIGHT 2020 American Society for Clinical Investigation</rights><rights>Copyright American Society for Clinical Investigation Aug 2020</rights><rights>2020 American Society for Clinical Investigation 2020 American Society for Clinical Investigation</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c607t-715e6420028b2243c1a13275ad44249b6f2e949ef2aeb5eaa13d21a92b32093f3</citedby><cites>FETCH-LOGICAL-c607t-715e6420028b2243c1a13275ad44249b6f2e949ef2aeb5eaa13d21a92b32093f3</cites><orcidid>0000-0001-5096-6549 ; 0000-0001-8375-7719 ; 0000-0001-6539-095X ; 0000-0001-7711-3597</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410047/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7410047/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32427584$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smith, Kimberly R</creatorcontrib><creatorcontrib>Papantoni, Afroditi</creatorcontrib><creatorcontrib>Veldhuizen, Maria G</creatorcontrib><creatorcontrib>Kamath, Vidyulata</creatorcontrib><creatorcontrib>Harris, Civonnia</creatorcontrib><creatorcontrib>Moran, Timothy H</creatorcontrib><creatorcontrib>Carnell, Susan</creatorcontrib><creatorcontrib>Steele, Kimberley E</creatorcontrib><title>Taste-related reward is associated with weight loss following bariatric surgery</title><title>The Journal of clinical investigation</title><addtitle>J Clin Invest</addtitle><description>BACKGROUNDBariatric surgeries are the most effective treatments for successful and sustained weight loss, but individuals vary in treatment response. Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic approaches and improve treatment outcomes. The primary objectives of this study were to investigate changes in taste preferences and taste-induced brain responses after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) and to identify potential taste-related predictors of weight loss.METHODSFemales, ages 18 to 55, with a body mass index greater than or equal to 35 kg/m2, and approved for bariatric surgery at the Johns Hopkins Center for Bariatric Surgery were recruited for participation. Demographics, anthropometrics, liking ratings, and neural responses to varying concentrations of sucrose plus fat mixtures were assessed before and after surgery via visual analog scales and functional MRI.RESULTSBariatric surgery produced decreases in liking for sucrose-sweetened mixtures. Greater preference for sucrose-sweetened mixtures before surgery was associated with greater weight loss in RYGB, but not VSG. In the RYGB group only, individuals who showed lower taste-induced activation in the ventral tegmental area (VTA) before surgery and greater changes in taste-induced VTA activation 2 weeks following surgery experienced increased weight loss.CONCLUSIONThe anatomical and/or metabolic changes associated with RYGB may more effectively "reset" the neural processing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in patients with obesity. Further, these findings suggest that RYGB may be particularly effective in patients with a preference for sweet foods.FUNDINGNIH K23DK100559 and Dalio Philanthropies.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bariatric surgery</subject><subject>Biomedical research</subject><subject>Body mass index</subject><subject>Body weight loss</subject><subject>Care and treatment</subject><subject>Clinical Medicine</subject><subject>Demographics</subject><subject>Demography</subject><subject>Dopamine</subject><subject>Female</subject><subject>Food</subject><subject>Food preferences</subject><subject>Functional magnetic resonance imaging</subject><subject>Gastrectomy</subject><subject>Gastric Bypass</subject><subject>Gastroesophageal reflux</subject><subject>Gastrointestinal surgery</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Information processing</subject><subject>Mesolimbic system</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Obesity - surgery</subject><subject>Patients</subject><subject>Preferences</subject><subject>Ratings & rankings</subject><subject>Reinforcement</subject><subject>Sucrose</subject><subject>Surgery</subject><subject>Sweet taste</subject><subject>Taste</subject><subject>Taste preferences</subject><subject>Ventral tegmentum</subject><subject>Weight control</subject><subject>Weight Loss</subject><subject>Weight loss maintenance</subject><issn>0021-9738</issn><issn>1558-8238</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkl1rFDEUhoNY7Fq98A_IgCB6MTVfs5m5Ecrix5bCglZvQyZzZiYlm9Qk49p_b_rhtlv2QnIROOc5b95wXoReEXxMiKAfThdLwoQQ9Amakaqqy5qy-imaYUxJ2QhWH6LnMV5gTDiv-DN0yCinoqr5DK3OVUxQBrAqQVcE2KjQFSYWKkavzU1xY9JYbMAMYyqsj7HovbV-Y9xQtCpkJhhdxCkMEK5eoINe2Qgv7-4j9OPzp_PF1_Js9WW5ODkr9RyLVApSwZzTbLBuKeVME0VYtqQ6zilv2nlPoeEN9FRBW4HK3Y4S1dCWUdywnh2hj7e6l1O7hk6DS0FZeRnMWoUr6ZWRux1nRjn431JwgjEXWeDdnUDwvyaISa5N1GCtcuCnKCnHFcOC8Sajbx6hF34KLn8vU4zUrMKY3VODsiCN631-V1-LypM5Y4IIjkmmyj3UAA6ySe-gN7m8wx_v4fPpYG303oH3OwOZSfAnDWqKUS6_f_t_dvVzl337gB1B2TRGb6dkvIt7RXXIWQnQb5dCsLyOq9zGNbOvH25xS_7LJ_sLrk_f7Q</recordid><startdate>20200801</startdate><enddate>20200801</enddate><creator>Smith, Kimberly R</creator><creator>Papantoni, Afroditi</creator><creator>Veldhuizen, Maria G</creator><creator>Kamath, Vidyulata</creator><creator>Harris, Civonnia</creator><creator>Moran, Timothy H</creator><creator>Carnell, Susan</creator><creator>Steele, Kimberley E</creator><general>American Society for Clinical Investigation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>S0X</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5096-6549</orcidid><orcidid>https://orcid.org/0000-0001-8375-7719</orcidid><orcidid>https://orcid.org/0000-0001-6539-095X</orcidid><orcidid>https://orcid.org/0000-0001-7711-3597</orcidid></search><sort><creationdate>20200801</creationdate><title>Taste-related reward is associated with weight loss following bariatric surgery</title><author>Smith, Kimberly R ; Papantoni, Afroditi ; Veldhuizen, Maria G ; Kamath, Vidyulata ; Harris, Civonnia ; Moran, Timothy H ; Carnell, Susan ; Steele, Kimberley E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c607t-715e6420028b2243c1a13275ad44249b6f2e949ef2aeb5eaa13d21a92b32093f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bariatric surgery</topic><topic>Biomedical research</topic><topic>Body mass index</topic><topic>Body weight loss</topic><topic>Care and treatment</topic><topic>Clinical Medicine</topic><topic>Demographics</topic><topic>Demography</topic><topic>Dopamine</topic><topic>Female</topic><topic>Food</topic><topic>Food preferences</topic><topic>Functional magnetic resonance imaging</topic><topic>Gastrectomy</topic><topic>Gastric Bypass</topic><topic>Gastroesophageal reflux</topic><topic>Gastrointestinal surgery</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Information processing</topic><topic>Mesolimbic system</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Obesity - surgery</topic><topic>Patients</topic><topic>Preferences</topic><topic>Ratings & rankings</topic><topic>Reinforcement</topic><topic>Sucrose</topic><topic>Surgery</topic><topic>Sweet taste</topic><topic>Taste</topic><topic>Taste preferences</topic><topic>Ventral tegmentum</topic><topic>Weight control</topic><topic>Weight Loss</topic><topic>Weight loss maintenance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smith, Kimberly R</creatorcontrib><creatorcontrib>Papantoni, Afroditi</creatorcontrib><creatorcontrib>Veldhuizen, Maria G</creatorcontrib><creatorcontrib>Kamath, Vidyulata</creatorcontrib><creatorcontrib>Harris, Civonnia</creatorcontrib><creatorcontrib>Moran, Timothy H</creatorcontrib><creatorcontrib>Carnell, Susan</creatorcontrib><creatorcontrib>Steele, Kimberley E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smith, Kimberly R</au><au>Papantoni, Afroditi</au><au>Veldhuizen, Maria G</au><au>Kamath, Vidyulata</au><au>Harris, Civonnia</au><au>Moran, Timothy H</au><au>Carnell, Susan</au><au>Steele, Kimberley E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Taste-related reward is associated with weight loss following bariatric surgery</atitle><jtitle>The Journal of clinical investigation</jtitle><addtitle>J Clin Invest</addtitle><date>2020-08-01</date><risdate>2020</risdate><volume>130</volume><issue>8</issue><spage>4370</spage><epage>4381</epage><pages>4370-4381</pages><issn>0021-9738</issn><eissn>1558-8238</eissn><abstract>BACKGROUNDBariatric surgeries are the most effective treatments for successful and sustained weight loss, but individuals vary in treatment response. Understanding the neurobiological and behavioral mechanisms accounting for this variation could lead to the development of personalized therapeutic approaches and improve treatment outcomes. The primary objectives of this study were to investigate changes in taste preferences and taste-induced brain responses after Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (VSG) and to identify potential taste-related predictors of weight loss.METHODSFemales, ages 18 to 55, with a body mass index greater than or equal to 35 kg/m2, and approved for bariatric surgery at the Johns Hopkins Center for Bariatric Surgery were recruited for participation. Demographics, anthropometrics, liking ratings, and neural responses to varying concentrations of sucrose plus fat mixtures were assessed before and after surgery via visual analog scales and functional MRI.RESULTSBariatric surgery produced decreases in liking for sucrose-sweetened mixtures. Greater preference for sucrose-sweetened mixtures before surgery was associated with greater weight loss in RYGB, but not VSG. In the RYGB group only, individuals who showed lower taste-induced activation in the ventral tegmental area (VTA) before surgery and greater changes in taste-induced VTA activation 2 weeks following surgery experienced increased weight loss.CONCLUSIONThe anatomical and/or metabolic changes associated with RYGB may more effectively "reset" the neural processing of reward stimuli, thereby rescuing the blunted activation in the mesolimbic pathway found in patients with obesity. Further, these findings suggest that RYGB may be particularly effective in patients with a preference for sweet foods.FUNDINGNIH K23DK100559 and Dalio Philanthropies.</abstract><cop>United States</cop><pub>American Society for Clinical Investigation</pub><pmid>32427584</pmid><doi>10.1172/JCI137772</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5096-6549</orcidid><orcidid>https://orcid.org/0000-0001-8375-7719</orcidid><orcidid>https://orcid.org/0000-0001-6539-095X</orcidid><orcidid>https://orcid.org/0000-0001-7711-3597</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Bariatric surgery Biomedical research Body mass index Body weight loss Care and treatment Clinical Medicine Demographics Demography Dopamine Female Food Food preferences Functional magnetic resonance imaging Gastrectomy Gastric Bypass Gastroesophageal reflux Gastrointestinal surgery Health aspects Humans Information processing Mesolimbic system Middle Aged Obesity Obesity - physiopathology Obesity - surgery Patients Preferences Ratings & rankings Reinforcement Sucrose Surgery Sweet taste Taste Taste preferences Ventral tegmentum Weight control Weight Loss Weight loss maintenance |
| title | Taste-related reward is associated with weight loss following bariatric surgery |
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