Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry
Background: The impact of pancreas transplantation, including kidney transplantation on patients’ life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transp...
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| Veröffentlicht in: | Journal of clinical medicine 2020-07, Vol.9 (7), p.2134 |
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| creator | Ito, Taihei Kenmochi, Takashi Aida, Naohiro Matsushima, Hajime Kurihara, Kei Ishihara, Takuma Shintani, Ayumi Asaoka, Tadafumi Ito, Toshinori |
| description | Background: The impact of pancreas transplantation, including kidney transplantation on patients’ life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation. Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Results: The survival rates at 1, 5, and 10 years on the waiting list were 98.4%, 90.3%, and 78.1%, respectively, while those after transplantation were significantly improved (p = 0.029) at 100%, 97.5%, and 88.9%, respectively. Furthermore, the survival rates of patients waiting for simultaneous pancreas and kidney transplantation (SPK) at 1, 5, and 10 years were 98.2%, 89.4%, and 75.4%, respectively, while those after SPK were also significantly improved (p = 0.026) at 100%, 94.6%, and 88.8%. The multivariable analysis revealed that the duration of diabetes before surgery was the only independent risk factor (hazard ratio = 1.095, p = 0.012) that affected the patient survival after SPK. Conclusion: Pancreas transplantation was found to improve the life prognosis of patients with type 1 diabetes, especially those with end-stage renal failure waiting for SPK. |
| doi_str_mv | 10.3390/jcm9072134 |
| format | Article |
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An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation. Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Results: The survival rates at 1, 5, and 10 years on the waiting list were 98.4%, 90.3%, and 78.1%, respectively, while those after transplantation were significantly improved (p = 0.029) at 100%, 97.5%, and 88.9%, respectively. Furthermore, the survival rates of patients waiting for simultaneous pancreas and kidney transplantation (SPK) at 1, 5, and 10 years were 98.2%, 89.4%, and 75.4%, respectively, while those after SPK were also significantly improved (p = 0.026) at 100%, 94.6%, and 88.8%. The multivariable analysis revealed that the duration of diabetes before surgery was the only independent risk factor (hazard ratio = 1.095, p = 0.012) that affected the patient survival after SPK. Conclusion: Pancreas transplantation was found to improve the life prognosis of patients with type 1 diabetes, especially those with end-stage renal failure waiting for SPK.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm9072134</identifier><identifier>PMID: 32640735</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Age ; Clinical medicine ; Committees ; Diabetes ; Diabetic retinopathy ; Glucose ; Insulin ; Kidney transplants ; Medical prognosis ; Pancreas transplants ; Patients ; Registration ; Regression analysis ; Waiting period</subject><ispartof>Journal of clinical medicine, 2020-07, Vol.9 (7), p.2134</ispartof><rights>2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-86db7085a5001e5c54451e9a780384142d7259b95aa5e380c52f9fcce4346cdf3</citedby><cites>FETCH-LOGICAL-c449t-86db7085a5001e5c54451e9a780384142d7259b95aa5e380c52f9fcce4346cdf3</cites><orcidid>0000-0001-8423-2885 ; 0000-0001-9666-4730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7408615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids></links><search><creatorcontrib>Ito, Taihei</creatorcontrib><creatorcontrib>Kenmochi, Takashi</creatorcontrib><creatorcontrib>Aida, Naohiro</creatorcontrib><creatorcontrib>Matsushima, Hajime</creatorcontrib><creatorcontrib>Kurihara, Kei</creatorcontrib><creatorcontrib>Ishihara, Takuma</creatorcontrib><creatorcontrib>Shintani, Ayumi</creatorcontrib><creatorcontrib>Asaoka, Tadafumi</creatorcontrib><creatorcontrib>Ito, Toshinori</creatorcontrib><title>Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry</title><title>Journal of clinical medicine</title><description>Background: The impact of pancreas transplantation, including kidney transplantation on patients’ life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation. Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Results: The survival rates at 1, 5, and 10 years on the waiting list were 98.4%, 90.3%, and 78.1%, respectively, while those after transplantation were significantly improved (p = 0.029) at 100%, 97.5%, and 88.9%, respectively. Furthermore, the survival rates of patients waiting for simultaneous pancreas and kidney transplantation (SPK) at 1, 5, and 10 years were 98.2%, 89.4%, and 75.4%, respectively, while those after SPK were also significantly improved (p = 0.026) at 100%, 94.6%, and 88.8%. The multivariable analysis revealed that the duration of diabetes before surgery was the only independent risk factor (hazard ratio = 1.095, p = 0.012) that affected the patient survival after SPK. Conclusion: Pancreas transplantation was found to improve the life prognosis of patients with type 1 diabetes, especially those with end-stage renal failure waiting for SPK.</description><subject>Age</subject><subject>Clinical medicine</subject><subject>Committees</subject><subject>Diabetes</subject><subject>Diabetic retinopathy</subject><subject>Glucose</subject><subject>Insulin</subject><subject>Kidney transplants</subject><subject>Medical prognosis</subject><subject>Pancreas transplants</subject><subject>Patients</subject><subject>Registration</subject><subject>Regression analysis</subject><subject>Waiting period</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkd1KHDEUgEOpqGy96RMM9EYKq_mdTG4Ki_jLQqW11-FsNqNZZjJjklnYOx_CJ_RJzLCL1tJwIAfOx8f5QegrwSeMKXy6Mq3CkhLGP6FDiqWcYlaxz3_lB-goxhXOr6o4JXIfHTBaciyZOETr67YHk4quLm7Bm2AhFncBfOwb8AmS63yRIz3YXE_O-lT8HsLaraF5eXqe-WLmodlEF0fDSN1AD95G-z9dLH7ZexdT2HxBezU00R7t_gn6c3F-d3Y1nf-8vD6bzaeGc5WmVblcSFwJEBgTK4zgXBCrQFZ5ME44XUoq1EIJAGFZhY2gtaqNsZzx0ixrNkE_tt5-WLR2aXL_ARrdB9dC2OgOnP5Y8e5B33drLTmuSiKy4HgnCN3jYGPSrYvGNnkc2w1RU04pxkrREf32D7rqhpDXk6mSEyIIZSP1fUuZ0MUYbP3WDMF6vKh-vyh7BfzOlAk</recordid><startdate>20200706</startdate><enddate>20200706</enddate><creator>Ito, Taihei</creator><creator>Kenmochi, Takashi</creator><creator>Aida, Naohiro</creator><creator>Matsushima, Hajime</creator><creator>Kurihara, Kei</creator><creator>Ishihara, Takuma</creator><creator>Shintani, Ayumi</creator><creator>Asaoka, Tadafumi</creator><creator>Ito, Toshinori</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8423-2885</orcidid><orcidid>https://orcid.org/0000-0001-9666-4730</orcidid></search><sort><creationdate>20200706</creationdate><title>Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry</title><author>Ito, Taihei ; Kenmochi, Takashi ; Aida, Naohiro ; Matsushima, Hajime ; Kurihara, Kei ; Ishihara, Takuma ; Shintani, Ayumi ; Asaoka, Tadafumi ; Ito, Toshinori</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-86db7085a5001e5c54451e9a780384142d7259b95aa5e380c52f9fcce4346cdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Clinical medicine</topic><topic>Committees</topic><topic>Diabetes</topic><topic>Diabetic retinopathy</topic><topic>Glucose</topic><topic>Insulin</topic><topic>Kidney transplants</topic><topic>Medical prognosis</topic><topic>Pancreas transplants</topic><topic>Patients</topic><topic>Registration</topic><topic>Regression analysis</topic><topic>Waiting period</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ito, Taihei</creatorcontrib><creatorcontrib>Kenmochi, Takashi</creatorcontrib><creatorcontrib>Aida, Naohiro</creatorcontrib><creatorcontrib>Matsushima, Hajime</creatorcontrib><creatorcontrib>Kurihara, Kei</creatorcontrib><creatorcontrib>Ishihara, Takuma</creatorcontrib><creatorcontrib>Shintani, Ayumi</creatorcontrib><creatorcontrib>Asaoka, Tadafumi</creatorcontrib><creatorcontrib>Ito, Toshinori</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ito, Taihei</au><au>Kenmochi, Takashi</au><au>Aida, Naohiro</au><au>Matsushima, Hajime</au><au>Kurihara, Kei</au><au>Ishihara, Takuma</au><au>Shintani, Ayumi</au><au>Asaoka, Tadafumi</au><au>Ito, Toshinori</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry</atitle><jtitle>Journal of clinical medicine</jtitle><date>2020-07-06</date><risdate>2020</risdate><volume>9</volume><issue>7</issue><spage>2134</spage><pages>2134-</pages><issn>2077-0383</issn><eissn>2077-0383</eissn><abstract>Background: The impact of pancreas transplantation, including kidney transplantation on patients’ life prognoses, is unclear in Japan. An analysis of the data of the Japan Pancreas Transplant Registry was performed to compare the patient survival between on the waiting list and after pancreas transplantation, and investigate the factors that affect the patient survival after pancreatic transplantation. Methods: The life prognoses of 361 patients who underwent pancreas transplantation from 2000 to December 2018 were examined. Results: The survival rates at 1, 5, and 10 years on the waiting list were 98.4%, 90.3%, and 78.1%, respectively, while those after transplantation were significantly improved (p = 0.029) at 100%, 97.5%, and 88.9%, respectively. Furthermore, the survival rates of patients waiting for simultaneous pancreas and kidney transplantation (SPK) at 1, 5, and 10 years were 98.2%, 89.4%, and 75.4%, respectively, while those after SPK were also significantly improved (p = 0.026) at 100%, 94.6%, and 88.8%. The multivariable analysis revealed that the duration of diabetes before surgery was the only independent risk factor (hazard ratio = 1.095, p = 0.012) that affected the patient survival after SPK. Conclusion: Pancreas transplantation was found to improve the life prognosis of patients with type 1 diabetes, especially those with end-stage renal failure waiting for SPK.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>32640735</pmid><doi>10.3390/jcm9072134</doi><orcidid>https://orcid.org/0000-0001-8423-2885</orcidid><orcidid>https://orcid.org/0000-0001-9666-4730</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Clinical medicine Committees Diabetes Diabetic retinopathy Glucose Insulin Kidney transplants Medical prognosis Pancreas transplants Patients Registration Regression analysis Waiting period |
| title | Impact of Pancreas Transplantation on the Patient Survival—An Analysis of the Japanese Pancreas Transplants Registry |
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