Stromal β-catenin activation impacts nephron progenitor differentiation in the developing kidney and may contribute to Wilms tumor

Wilms' tumor (WT) morphologically resembles the embryonic kidney, consisting of blastema, epithelial and stromal components, suggesting tumors arise from the dysregulation of normal development. β-Catenin activation is observed in a significant proportion of WTs; however, much remains to be und...

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Veröffentlicht in:	Development (Cambridge) 2020-07, Vol.147 (21)
Hauptverfasser:	Drake, Keri A, Chaney, Christopher P, Das, Amrita, Roy, Priti, Kwartler, Callie S, Rakheja, Dinesh, Carroll, Thomas J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Base Sequence beta Catenin - genetics beta Catenin - metabolism Body Patterning - genetics Cell Differentiation - genetics Cell Lineage - genetics Epithelium - embryology Forkhead Transcription Factors - metabolism Gene Expression Regulation, Neoplastic Humans Integrases - metabolism Mesoderm - embryology Mice Mutation - genetics Nephrons - metabolism Nephrons - pathology Organogenesis - genetics Osteogenesis - genetics Stem Cells - metabolism Stromal Cells - metabolism Stromal Cells - pathology Transcriptome - genetics Wilms Tumor - genetics Wilms Tumor - metabolism Wilms Tumor - pathology
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