Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment

Retinal detachment (RD) disrupts the nutritional support and oxygen delivery to photoreceptors (PRs), ultimately causing cell death. High-mobility group box 1 (HMGB1) can serve as an extracellular alarmin when released from stressed cells. PRs release HMGB1 after RD. The purpose of this study was to...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2020-05, Vol.61 (5), p.50-50
Hauptverfasser:	Ross, Bing X, Choi, Joanne, Yao, Jingyu, Hager, Heather M, Abcouwer, Steven F, Zacks, David N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals HMGB1 Protein - metabolism Mice Mice, Inbred C57BL Retina Retinal Degeneration - etiology Retinal Detachment - complications Retinal Detachment - metabolism Retinal Rod Photoreceptor Cells - metabolism Time Factors
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