Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

Our understanding of Alzheimer’s disease (AD) pathophysiology remains incomplete. Here we used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD. A protein network module linked to sugar metabolism emerged as one of the modules mos...

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Veröffentlicht in:	Nature medicine 2020-05, Vol.26 (5), p.769-780
Hauptverfasser:	Johnson, Erik C. B., Dammer, Eric B., Duong, Duc M., Ping, Lingyan, Zhou, Maotian, Yin, Luming, Higginbotham, Lenora A., Guajardo, Andrew, White, Bartholomew, Troncoso, Juan C., Thambisetty, Madhav, Montine, Thomas J., Lee, Edward B., Trojanowski, John Q., Beach, Thomas G., Reiman, Eric M., Haroutunian, Vahram, Wang, Minghui, Schadt, Eric, Zhang, Bin, Dickson, Dennis W., Ertekin-Taner, Nilüfer, Golde, Todd E., Petyuk, Vladislav A., De Jager, Philip L., Bennett, David A., Wingo, Thomas S., Rangaraju, Srikant, Hajjar, Ihab, Shulman, Joshua M., Lah, James J., Levey, Allan I., Seyfried, Nicholas T.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES 631/114/2784 631/553/1833 692/53/2421 692/699/375/365/1283 Alzheimer Disease - cerebrospinal fluid Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Analysis Animals Astrocytes Astrocytes - metabolism Astrocytes - pathology Astrocytes - physiology Bioenergetics Biological activity Biomarkers Biomarkers - cerebrospinal fluid Biomarkers - metabolism Biomedical and Life Sciences Biomedicine Brain Brain - metabolism Brain - pathology Cancer Research Case-Control Studies Cerebrospinal fluid Cerebrospinal Fluid - chemistry Cerebrospinal Fluid - metabolism Cognitive ability Cohort Studies Development and progression diagnostic markers Disease Progression Energy Metabolism Female Gene Regulatory Networks - physiology Genetic aspects Health aspects Humans Infectious Diseases Inflammation Male Mass Spectrometry Mass spectroscopy Metabolic Diseases Metabolic Networks and Pathways Metabolism Mice Microglia Microglia - metabolism Microglia - pathology Microglia - physiology Modules Molecular Medicine Nerve Tissue Proteins - analysis Nerve Tissue Proteins - cerebrospinal fluid Nerve Tissue Proteins - metabolism Network analysis Neurodegenerative diseases Neurogenesis - physiology Neurosciences Pathogenesis Pathophysiology Physiological aspects Protein turnover Proteins proteome informatics Proteomics Proteomics - methods Resource Risk analysis Risk factors Sample Size systems analysis Therapeutic applications Time Factors
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