Benzothiazoles as potential antiviral agents
Abstract Objectives The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urg...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmacy and pharmacology 2020-11, Vol.72 (11), p.1459-1480 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1480 |
|---|---|
| container_issue | 11 |
| container_start_page | 1459 |
| container_title | Journal of pharmacy and pharmacology |
| container_volume | 72 |
| creator | Asiri, Yahya I Alsayari, Abdulrhman Muhsinah, Abdullatif B Mabkhot, Yahia N Hassan, Mohd Z |
| description | Abstract
Objectives
The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic.
Key findings
Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole-based antiviral agents, with a special focus on their structure-activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review.
Summary
We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad-spectrum benzothiazole-based antiviral agents to be used against emerging viral diseases. |
| doi_str_mv | 10.1111/jphp.13331 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405065</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1111/jphp.13331</oup_id><sourcerecordid>2448516047</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5061-20dec90a9f9ebb0d08b6ae878f9de0bd58b68ab050705da13d58473d6f98a083</originalsourceid><addsrcrecordid>eNp9kVFPwjAQxxujEURf_ACGxJgY4_Dabm33YqJERUMiD7w33dbByFjnyjDw6S0OiPpgX669_u5___YQOsfQw27dzcpp2cOUUnyA2gR84nEciEPUBiDEowGnLXRi7QwAOGPsGLUo4RCwENro9lEXa7OYZmptcm27ynZLs9DFIlN5V7mwzKrNbuJS9hQdpSq3-mwbO2j8_DTuD7zh-8tr_2HoxQEw7BFIdByCCtNQRxEkICKmtOAiDRMNURK4s1ARBOBcJApTl_E5TVgaCgWCdtB9I1vW0VwnsWvtPMiyyuaqWkmjMvn7psimcmKWkvtOkwVO4HorUJmPWtuFnGc21nmuCm1qK4lPOAUqgDj08g86M3VVuNc5yhcBZuCsddBNQ8WVsbbS6d4MBrmZgdzMQH7PwMEXP-3v0d2nOwA3wGeW69U_UvJtNBjtRK-aGlOX_zX_Aochnag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2448516047</pqid></control><display><type>article</type><title>Benzothiazoles as potential antiviral agents</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><source>Oxford University Press Journals All Titles (1996-Current)</source><creator>Asiri, Yahya I ; Alsayari, Abdulrhman ; Muhsinah, Abdullatif B ; Mabkhot, Yahia N ; Hassan, Mohd Z</creator><creatorcontrib>Asiri, Yahya I ; Alsayari, Abdulrhman ; Muhsinah, Abdullatif B ; Mabkhot, Yahia N ; Hassan, Mohd Z</creatorcontrib><description>Abstract
Objectives
The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic.
Key findings
Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole-based antiviral agents, with a special focus on their structure-activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review.
Summary
We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad-spectrum benzothiazole-based antiviral agents to be used against emerging viral diseases.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1111/jphp.13331</identifier><identifier>PMID: 32705690</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>antiviral ; Antiviral agents ; Antiviral Agents - pharmacology ; Antiviral Agents - therapeutic use ; Benzothiazole ; Benzothiazoles - pharmacology ; Benzothiazoles - therapeutic use ; COVID-19 - drug therapy ; COVID‐19 ; dengue ; Drug Design ; HIV ; Humans ; Pandemics ; Review ; Structure-Activity Relationship ; Viral diseases</subject><ispartof>Journal of pharmacy and pharmacology, 2020-11, Vol.72 (11), p.1459-1480</ispartof><rights>2020 Royal Pharmaceutical Society 2020</rights><rights>2020 Royal Pharmaceutical Society</rights><rights>2020 Royal Pharmaceutical Society.</rights><rights>Copyright © 2020 Royal Pharmaceutical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5061-20dec90a9f9ebb0d08b6ae878f9de0bd58b68ab050705da13d58473d6f98a083</citedby><cites>FETCH-LOGICAL-c5061-20dec90a9f9ebb0d08b6ae878f9de0bd58b68ab050705da13d58473d6f98a083</cites><orcidid>0000-0002-8235-5379</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjphp.13331$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjphp.13331$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32705690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asiri, Yahya I</creatorcontrib><creatorcontrib>Alsayari, Abdulrhman</creatorcontrib><creatorcontrib>Muhsinah, Abdullatif B</creatorcontrib><creatorcontrib>Mabkhot, Yahia N</creatorcontrib><creatorcontrib>Hassan, Mohd Z</creatorcontrib><title>Benzothiazoles as potential antiviral agents</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Abstract
Objectives
The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic.
Key findings
Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole-based antiviral agents, with a special focus on their structure-activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review.
Summary
We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad-spectrum benzothiazole-based antiviral agents to be used against emerging viral diseases.</description><subject>antiviral</subject><subject>Antiviral agents</subject><subject>Antiviral Agents - pharmacology</subject><subject>Antiviral Agents - therapeutic use</subject><subject>Benzothiazole</subject><subject>Benzothiazoles - pharmacology</subject><subject>Benzothiazoles - therapeutic use</subject><subject>COVID-19 - drug therapy</subject><subject>COVID‐19</subject><subject>dengue</subject><subject>Drug Design</subject><subject>HIV</subject><subject>Humans</subject><subject>Pandemics</subject><subject>Review</subject><subject>Structure-Activity Relationship</subject><subject>Viral diseases</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kVFPwjAQxxujEURf_ACGxJgY4_Dabm33YqJERUMiD7w33dbByFjnyjDw6S0OiPpgX669_u5___YQOsfQw27dzcpp2cOUUnyA2gR84nEciEPUBiDEowGnLXRi7QwAOGPsGLUo4RCwENro9lEXa7OYZmptcm27ynZLs9DFIlN5V7mwzKrNbuJS9hQdpSq3-mwbO2j8_DTuD7zh-8tr_2HoxQEw7BFIdByCCtNQRxEkICKmtOAiDRMNURK4s1ARBOBcJApTl_E5TVgaCgWCdtB9I1vW0VwnsWvtPMiyyuaqWkmjMvn7psimcmKWkvtOkwVO4HorUJmPWtuFnGc21nmuCm1qK4lPOAUqgDj08g86M3VVuNc5yhcBZuCsddBNQ8WVsbbS6d4MBrmZgdzMQH7PwMEXP-3v0d2nOwA3wGeW69U_UvJtNBjtRK-aGlOX_zX_Aochnag</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Asiri, Yahya I</creator><creator>Alsayari, Abdulrhman</creator><creator>Muhsinah, Abdullatif B</creator><creator>Mabkhot, Yahia N</creator><creator>Hassan, Mohd Z</creator><general>Oxford University Press</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8235-5379</orcidid></search><sort><creationdate>202011</creationdate><title>Benzothiazoles as potential antiviral agents</title><author>Asiri, Yahya I ; Alsayari, Abdulrhman ; Muhsinah, Abdullatif B ; Mabkhot, Yahia N ; Hassan, Mohd Z</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5061-20dec90a9f9ebb0d08b6ae878f9de0bd58b68ab050705da13d58473d6f98a083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>antiviral</topic><topic>Antiviral agents</topic><topic>Antiviral Agents - pharmacology</topic><topic>Antiviral Agents - therapeutic use</topic><topic>Benzothiazole</topic><topic>Benzothiazoles - pharmacology</topic><topic>Benzothiazoles - therapeutic use</topic><topic>COVID-19 - drug therapy</topic><topic>COVID‐19</topic><topic>dengue</topic><topic>Drug Design</topic><topic>HIV</topic><topic>Humans</topic><topic>Pandemics</topic><topic>Review</topic><topic>Structure-Activity Relationship</topic><topic>Viral diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asiri, Yahya I</creatorcontrib><creatorcontrib>Alsayari, Abdulrhman</creatorcontrib><creatorcontrib>Muhsinah, Abdullatif B</creatorcontrib><creatorcontrib>Mabkhot, Yahia N</creatorcontrib><creatorcontrib>Hassan, Mohd Z</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asiri, Yahya I</au><au>Alsayari, Abdulrhman</au><au>Muhsinah, Abdullatif B</au><au>Mabkhot, Yahia N</au><au>Hassan, Mohd Z</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Benzothiazoles as potential antiviral agents</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2020-11</date><risdate>2020</risdate><volume>72</volume><issue>11</issue><spage>1459</spage><epage>1480</epage><pages>1459-1480</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Abstract
Objectives
The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic.
Key findings
Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole-based antiviral agents, with a special focus on their structure-activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review.
Summary
We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad-spectrum benzothiazole-based antiviral agents to be used against emerging viral diseases.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>32705690</pmid><doi>10.1111/jphp.13331</doi><tpages>22</tpages><orcidid>https://orcid.org/0000-0002-8235-5379</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3573 |
| ispartof | Journal of pharmacy and pharmacology, 2020-11, Vol.72 (11), p.1459-1480 |
| issn | 0022-3573 2042-7158 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405065 |
| source | MEDLINE; Access via Wiley Online Library; Oxford University Press Journals All Titles (1996-Current) |
| subjects | antiviral Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Benzothiazole Benzothiazoles - pharmacology Benzothiazoles - therapeutic use COVID-19 - drug therapy COVID‐19 dengue Drug Design HIV Humans Pandemics Review Structure-Activity Relationship Viral diseases |
| title | Benzothiazoles as potential antiviral agents |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T20%3A47%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Benzothiazoles%20as%20potential%20antiviral%20agents&rft.jtitle=Journal%20of%20pharmacy%20and%20pharmacology&rft.au=Asiri,%20Yahya%20I&rft.date=2020-11&rft.volume=72&rft.issue=11&rft.spage=1459&rft.epage=1480&rft.pages=1459-1480&rft.issn=0022-3573&rft.eissn=2042-7158&rft_id=info:doi/10.1111/jphp.13331&rft_dat=%3Cproquest_pubme%3E2448516047%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2448516047&rft_id=info:pmid/32705690&rft_oup_id=10.1111/jphp.13331&rfr_iscdi=true |