COVID‐19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the agent of novel coronavirus 2019 (COVID‐19), has kept the globe in disquiets due to its severe life‐threatening conditions. The most common symptoms of COVID‐19 are fever, sore throat, and shortness of breath. Accordin...
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| Veröffentlicht in: | Journal of cellular physiology 2021-02, Vol.236 (2), p.763-770 |
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| container_title | Journal of cellular physiology |
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| creator | Mahalaxmi, Iyer Kaavya, Jayaramayya Mohana Devi, Subramaniam Balachandar, Vellingiri |
| description | The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the agent of novel coronavirus 2019 (COVID‐19), has kept the globe in disquiets due to its severe life‐threatening conditions. The most common symptoms of COVID‐19 are fever, sore throat, and shortness of breath. According to the anecdotal reports from the health care workers, it has been suggested that the virus could reach the brain and can cause anosmia, hyposmia, hypogeusia, and hypopsia. Once the SARS‐CoV‐2 has entered the central nervous system (CNS), it can either exit in an inactive form in the tissues or may lead to neuroinflammation. Here, we aim to discuss the chronic infection of the olfactory bulb region of the brain by SARS‐CoV‐2 and how this could affect the nearby residing neurons in the host. We further review the probable cellular mechanism and activation of the microglia 1 phenotype possibly leading to various neurodegenerative disorders. In conclusion, SARS‐CoV‐2 might probably infect the olfactory bulb neuron enervating the nasal epithelium accessing the CNS and might cause neurodegenerative diseases in the future. |
| doi_str_mv | 10.1002/jcp.29937 |
| format | Article |
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The most common symptoms of COVID‐19 are fever, sore throat, and shortness of breath. According to the anecdotal reports from the health care workers, it has been suggested that the virus could reach the brain and can cause anosmia, hyposmia, hypogeusia, and hypopsia. Once the SARS‐CoV‐2 has entered the central nervous system (CNS), it can either exit in an inactive form in the tissues or may lead to neuroinflammation. Here, we aim to discuss the chronic infection of the olfactory bulb region of the brain by SARS‐CoV‐2 and how this could affect the nearby residing neurons in the host. We further review the probable cellular mechanism and activation of the microglia 1 phenotype possibly leading to various neurodegenerative disorders. In conclusion, SARS‐CoV‐2 might probably infect the olfactory bulb neuron enervating the nasal epithelium accessing the CNS and might cause neurodegenerative diseases in the future.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29937</identifier><identifier>PMID: 32697344</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Animals ; Anosmia ; Brain ; Central nervous system ; Chronic infection ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - complications ; Epithelium ; Fever ; Health care ; Humans ; Inflammation ; Medical personnel ; Microglia ; Mini‐review ; Mini‐reviews ; Neurodegenerative diseases ; Neurodegenerative Diseases - etiology ; neurodegenerative disorders ; neuroinflammation ; Olfaction ; Olfaction disorders ; Olfaction Disorders - etiology ; Olfactory bulb ; olfactory bulb dysfunction ; Pharyngitis ; Phenotypes ; Respiratory diseases ; SARS-CoV-2 ; SARS‐CoV‐2 neuroinvasion ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Signs and symptoms ; Smell ; Viral diseases ; Viruses</subject><ispartof>Journal of cellular physiology, 2021-02, Vol.236 (2), p.763-770</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5377-84171b518028aa468328dbb118197cddbfbbe81703b1c938a52ea28eb50be7863</citedby><cites>FETCH-LOGICAL-c5377-84171b518028aa468328dbb118197cddbfbbe81703b1c938a52ea28eb50be7863</cites><orcidid>0000-0002-8378-6197 ; 0000-0002-3043-6839</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.29937$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.29937$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32697344$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mahalaxmi, Iyer</creatorcontrib><creatorcontrib>Kaavya, Jayaramayya</creatorcontrib><creatorcontrib>Mohana Devi, Subramaniam</creatorcontrib><creatorcontrib>Balachandar, Vellingiri</creatorcontrib><title>COVID‐19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases</title><title>Journal of cellular physiology</title><addtitle>J Cell Physiol</addtitle><description>The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the agent of novel coronavirus 2019 (COVID‐19), has kept the globe in disquiets due to its severe life‐threatening conditions. The most common symptoms of COVID‐19 are fever, sore throat, and shortness of breath. According to the anecdotal reports from the health care workers, it has been suggested that the virus could reach the brain and can cause anosmia, hyposmia, hypogeusia, and hypopsia. Once the SARS‐CoV‐2 has entered the central nervous system (CNS), it can either exit in an inactive form in the tissues or may lead to neuroinflammation. Here, we aim to discuss the chronic infection of the olfactory bulb region of the brain by SARS‐CoV‐2 and how this could affect the nearby residing neurons in the host. We further review the probable cellular mechanism and activation of the microglia 1 phenotype possibly leading to various neurodegenerative disorders. In conclusion, SARS‐CoV‐2 might probably infect the olfactory bulb neuron enervating the nasal epithelium accessing the CNS and might cause neurodegenerative diseases in the future.</description><subject>Animals</subject><subject>Anosmia</subject><subject>Brain</subject><subject>Central nervous system</subject><subject>Chronic infection</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - complications</subject><subject>Epithelium</subject><subject>Fever</subject><subject>Health care</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Medical personnel</subject><subject>Microglia</subject><subject>Mini‐review</subject><subject>Mini‐reviews</subject><subject>Neurodegenerative diseases</subject><subject>Neurodegenerative Diseases - etiology</subject><subject>neurodegenerative disorders</subject><subject>neuroinflammation</subject><subject>Olfaction</subject><subject>Olfaction disorders</subject><subject>Olfaction Disorders - etiology</subject><subject>Olfactory bulb</subject><subject>olfactory bulb dysfunction</subject><subject>Pharyngitis</subject><subject>Phenotypes</subject><subject>Respiratory diseases</subject><subject>SARS-CoV-2</subject><subject>SARS‐CoV‐2 neuroinvasion</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Signs and symptoms</subject><subject>Smell</subject><subject>Viral diseases</subject><subject>Viruses</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10ctu1DAUBmALgehQWPACKBIbWKT1NXZYIFXDrahSWQBby5eTjkeZONhJq9n1EfqMPAmGlAqQWNnS-fTr2D9CTwk-IhjT460bj2jbMnkPrQhuZc0bQe-jVZmRuhWcHKBHOW8xxgWxh-iA0aaVjPMV2qzPv56--X59Q9rKDL6KfWfcFNO-8vvczYObQhxeVSfVGHMOtofK5BxdMFO4LPdxTNG4TTXFK5N8rgaYU_RwAQOkhfiQwWTIj9GDzvQZntyeh-jLu7ef1x_qs_P3p-uTs9oJJmWtOJHECqIwVcbwRjGqvLWEKNJK573trAVFJGaWuJYpIygYqsAKbEGqhh2i10vuONsdeAfDlEyvxxR2Ju11NEH_PRnCRl_ESy05FrihJeDFbUCK32bIk96F7KDvzQBxzppy2hAplJCFPv-HbuOchvK8ohrKBZWSFPVyUS6VP0zQ3S1DsP7Zny796V_9Ffvsz-3v5O_CCjhewFXoYf__JP1x_WmJ_AFtZabw</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Mahalaxmi, Iyer</creator><creator>Kaavya, Jayaramayya</creator><creator>Mohana Devi, Subramaniam</creator><creator>Balachandar, Vellingiri</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8378-6197</orcidid><orcidid>https://orcid.org/0000-0002-3043-6839</orcidid></search><sort><creationdate>202102</creationdate><title>COVID‐19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases</title><author>Mahalaxmi, Iyer ; Kaavya, Jayaramayya ; Mohana Devi, Subramaniam ; Balachandar, Vellingiri</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5377-84171b518028aa468328dbb118197cddbfbbe81703b1c938a52ea28eb50be7863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Anosmia</topic><topic>Brain</topic><topic>Central nervous system</topic><topic>Chronic infection</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>COVID-19</topic><topic>COVID-19 - complications</topic><topic>Epithelium</topic><topic>Fever</topic><topic>Health care</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Medical personnel</topic><topic>Microglia</topic><topic>Mini‐review</topic><topic>Mini‐reviews</topic><topic>Neurodegenerative diseases</topic><topic>Neurodegenerative Diseases - etiology</topic><topic>neurodegenerative disorders</topic><topic>neuroinflammation</topic><topic>Olfaction</topic><topic>Olfaction disorders</topic><topic>Olfaction Disorders - etiology</topic><topic>Olfactory bulb</topic><topic>olfactory bulb dysfunction</topic><topic>Pharyngitis</topic><topic>Phenotypes</topic><topic>Respiratory diseases</topic><topic>SARS-CoV-2</topic><topic>SARS‐CoV‐2 neuroinvasion</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Signs and symptoms</topic><topic>Smell</topic><topic>Viral diseases</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mahalaxmi, Iyer</creatorcontrib><creatorcontrib>Kaavya, Jayaramayya</creatorcontrib><creatorcontrib>Mohana Devi, Subramaniam</creatorcontrib><creatorcontrib>Balachandar, Vellingiri</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mahalaxmi, Iyer</au><au>Kaavya, Jayaramayya</au><au>Mohana Devi, Subramaniam</au><au>Balachandar, Vellingiri</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COVID‐19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases</atitle><jtitle>Journal of cellular physiology</jtitle><addtitle>J Cell Physiol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>236</volume><issue>2</issue><spage>763</spage><epage>770</epage><pages>763-770</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the agent of novel coronavirus 2019 (COVID‐19), has kept the globe in disquiets due to its severe life‐threatening conditions. 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| subjects | Animals Anosmia Brain Central nervous system Chronic infection Coronaviridae Coronaviruses COVID-19 COVID-19 - complications Epithelium Fever Health care Humans Inflammation Medical personnel Microglia Mini‐review Mini‐reviews Neurodegenerative diseases Neurodegenerative Diseases - etiology neurodegenerative disorders neuroinflammation Olfaction Olfaction disorders Olfaction Disorders - etiology Olfactory bulb olfactory bulb dysfunction Pharyngitis Phenotypes Respiratory diseases SARS-CoV-2 SARS‐CoV‐2 neuroinvasion Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Signs and symptoms Smell Viral diseases Viruses |
| title | COVID‐19 and olfactory dysfunction: A possible associative approach towards neurodegenerative diseases |
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