Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels

The ability of exogenous low ouabain concentrations to affect claudin expression and therefore epithelial barrier properties was demonstrated previously in cultured cell studies. We hypothesized that chronic elevation of circulating ouabain in vivo can affect the expression of claudins and tight jun...

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Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (14), p.5067
Hauptverfasser:	Markov, Alexander G, Fedorova, Arina A, Kravtsova, Violetta V, Bikmurzina, Anastasia E, Okorokova, Larisa S, Matchkov, Vladimir V, Cornelius, Valeria, Amasheh, Salah, Krivoi, Igor I
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding sites Blood circulation Blood vessels Brain - blood supply Brain - drug effects Capillary Permeability - drug effects Cell culture Cell Line Claudins - analysis Claudins - metabolism Colon Endothelium Enzymes In vivo methods and tests Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestine Intestines - drug effects Jejunum Kinases Lipopolysaccharides Male Na+/K+-exchanging ATPase Ouabain Ouabain - administration & dosage Ouabain - blood Ouabain - pharmacology Permeability Permeability - drug effects Phosphorylation Proteins Rats Rats, Wistar Studies Swine Tight Junctions - drug effects Tight Junctions - metabolism
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