Physiological and Pathophysiological Aspects of Primary Cilia-A Literature Review with View on Functional and Structural Relationships in Cartilage
Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular...
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| Veröffentlicht in: | International journal of molecular sciences 2020-07, Vol.21 (14), p.4959 |
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| creator | Barsch, Friedrich Niedermair, Tanja Mamilos, Andreas Schmitt, Volker H Grevenstein, David Babel, Maximilian Burgoyne, Thomas Shoemark, Amelia Brochhausen, Christoph |
| description | Cilia are cellular organelles that project from the cell. They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo- and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of 'Primary Cilia' (PC) in the context of osteoarthritis is not yet fully understood. The present review focuses on the current knowledge about PC and provide a short but not exhaustive overview of their role in cartilage. |
| doi_str_mv | 10.3390/ijms21144959 |
| format | Article |
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They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo- and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of 'Primary Cilia' (PC) in the context of osteoarthritis is not yet fully understood. The present review focuses on the current knowledge about PC and provide a short but not exhaustive overview of their role in cartilage.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21144959</identifier><identifier>PMID: 32674266</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abnormalities ; Animals ; Arthritis ; Biomedical materials ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cartilage, Articular - pathology ; Cartilage, Articular - physiology ; Cell adhesion & migration ; Cell cycle ; Cellular structure ; Cilia ; Cilia - pathology ; Cilia - physiology ; Homeostasis ; Homeostasis - physiology ; Humans ; Literature reviews ; Mechanotransduction, Cellular - physiology ; Mesenchyme ; Morphogenesis ; Morphogenesis - physiology ; Morphology ; Morphometry ; Organelles ; Osteoarthritis ; Osteoarthritis - pathology ; Physiology ; Proteins ; Review ; Structure-function relationships</subject><ispartof>International journal of molecular sciences, 2020-07, Vol.21 (14), p.4959</ispartof><rights>2020. 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They occur in nearly all non-hematopoietic tissues and have different functions in different tissues. In mesenchymal tissues primary cilia play a crucial role in the adequate morphogenesis during embryological development. In mature articular cartilage, primary cilia fulfil chemo- and mechanosensitive functions to adapt the cellular mechanisms on extracellular changes and thus, maintain tissue homeostasis and morphometry. Ciliary abnormalities in osteoarthritic cartilage could represent pathophysiological relationships between ciliary dysfunction and tissue deformation. Nevertheless, the molecular and pathophysiological relationships of 'Primary Cilia' (PC) in the context of osteoarthritis is not yet fully understood. 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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Abnormalities Animals Arthritis Biomedical materials Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - pathology Cartilage, Articular - physiology Cell adhesion & migration Cell cycle Cellular structure Cilia Cilia - pathology Cilia - physiology Homeostasis Homeostasis - physiology Humans Literature reviews Mechanotransduction, Cellular - physiology Mesenchyme Morphogenesis Morphogenesis - physiology Morphology Morphometry Organelles Osteoarthritis Osteoarthritis - pathology Physiology Proteins Review Structure-function relationships |
| title | Physiological and Pathophysiological Aspects of Primary Cilia-A Literature Review with View on Functional and Structural Relationships in Cartilage |
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