Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases

Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis....

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Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (14), p.4931
Hauptverfasser:	Jayakumar, Thanasekaran, Saravana Bhavan, Periyakali, Sheu, Joen-Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arthritis Biological effects Biological Products - therapeutic use Biomedical materials Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - enzymology Cartilage, Articular - pathology Chondrocytes - drug effects Chondrocytes - enzymology Collagen Cytokines Cytokines - physiology Disease Drug Evaluation, Preclinical Drugs Enzymes Extracellular matrix Extracellular Matrix Proteins - metabolism Forecasting Gene expression Humans Inflammation Iodoacetic Acid - toxicity Joint diseases Joints (anatomy) Kinases Mammals Matrix metalloproteinase Matrix Metalloproteinase Inhibitors - therapeutic use Matrix metalloproteinases Models, Animal Natural products NF-kappa B - metabolism Osteoarthritis Osteoarthritis - chemically induced Osteoarthritis - drug therapy Osteoarthritis - enzymology Osteoarthritis - pathology Pain Pathophysiology Proteins Proteolysis Proteolytic enzymes Rats Review Rheumatoid arthritis Self Medication Signal transduction Studies Subchondral bone Tetradecanoylphorbol Acetate - toxicity Tumor necrosis factor-TNF
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