Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases
Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis....
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| Veröffentlicht in: | International journal of molecular sciences 2020-07, Vol.21 (14), p.4931 |
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| description | Osteoarthritis (OA) is the most common type of arthritis that occurs in an aged population. It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have been paid attention to, due to their potential biological effects. The therapeutic value of natural products in OA has increased in reputation due to their clinical impact and insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs, for a long time. Recently, different types of compounds were reviewed for their biological activities. In this review, we summarize numerous natural products for the development of MMPs inhibitors in arthritic diseases and describe the major signaling targets that were involved for the treatments of these destructive joint diseases. |
| doi_str_mv | 10.3390/ijms21144931 |
| format | Article |
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It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have been paid attention to, due to their potential biological effects. The therapeutic value of natural products in OA has increased in reputation due to their clinical impact and insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs, for a long time. Recently, different types of compounds were reviewed for their biological activities. In this review, we summarize numerous natural products for the development of MMPs inhibitors in arthritic diseases and describe the major signaling targets that were involved for the treatments of these destructive joint diseases.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21144931</identifier><identifier>PMID: 32668590</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Arthritis ; Biological effects ; Biological Products - therapeutic use ; Biomedical materials ; Cartilage ; Cartilage (articular) ; Cartilage diseases ; Cartilage, Articular - drug effects ; Cartilage, Articular - enzymology ; Cartilage, Articular - pathology ; Chondrocytes - drug effects ; Chondrocytes - enzymology ; Collagen ; Cytokines ; Cytokines - physiology ; Disease ; Drug Evaluation, Preclinical ; Drugs ; Enzymes ; Extracellular matrix ; Extracellular Matrix Proteins - metabolism ; Forecasting ; Gene expression ; Humans ; Inflammation ; Iodoacetic Acid - toxicity ; Joint diseases ; Joints (anatomy) ; Kinases ; Mammals ; Matrix metalloproteinase ; Matrix Metalloproteinase Inhibitors - therapeutic use ; Matrix metalloproteinases ; Models, Animal ; Natural products ; NF-kappa B - metabolism ; Osteoarthritis ; Osteoarthritis - chemically induced ; Osteoarthritis - drug therapy ; Osteoarthritis - enzymology ; Osteoarthritis - pathology ; Pain ; Pathophysiology ; Proteins ; Proteolysis ; Proteolytic enzymes ; Rats ; Review ; Rheumatoid arthritis ; Self Medication ; Signal transduction ; Studies ; Subchondral bone ; Tetradecanoylphorbol Acetate - toxicity ; Tumor necrosis factor-TNF</subject><ispartof>International journal of molecular sciences, 2020-07, Vol.21 (14), p.4931</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). 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It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have been paid attention to, due to their potential biological effects. The therapeutic value of natural products in OA has increased in reputation due to their clinical impact and insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs, for a long time. Recently, different types of compounds were reviewed for their biological activities. In this review, we summarize numerous natural products for the development of MMPs inhibitors in arthritic diseases and describe the major signaling targets that were involved for the treatments of these destructive joint diseases.</description><subject>Animals</subject><subject>Arthritis</subject><subject>Biological effects</subject><subject>Biological Products - therapeutic use</subject><subject>Biomedical materials</subject><subject>Cartilage</subject><subject>Cartilage (articular)</subject><subject>Cartilage diseases</subject><subject>Cartilage, Articular - drug effects</subject><subject>Cartilage, Articular - enzymology</subject><subject>Cartilage, Articular - pathology</subject><subject>Chondrocytes - drug effects</subject><subject>Chondrocytes - enzymology</subject><subject>Collagen</subject><subject>Cytokines</subject><subject>Cytokines - physiology</subject><subject>Disease</subject><subject>Drug Evaluation, Preclinical</subject><subject>Drugs</subject><subject>Enzymes</subject><subject>Extracellular matrix</subject><subject>Extracellular Matrix Proteins - 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It affects any joints in the body and degenerates the articular cartilage and the subchondral bone. Despite the pathophysiology of OA being different, cartilage resorption is still a symbol of osteoarthritis. Matrix metalloproteinases (MMPs) are important proteolytic enzymes that degrade extra-cellular matrix proteins (ECM) in the body. MMPs contribute to the turnover of cartilage and its break down; their levels have increased in the joint tissues of OA patients. Application of chondroprotective drugs neutralize the activities of MMPs. Natural products derived from herbs and plants developed as traditional medicine have been paid attention to, due to their potential biological effects. The therapeutic value of natural products in OA has increased in reputation due to their clinical impact and insignificant side effects. Several MMPs inhibitor have been used as therapeutic drugs, for a long time. Recently, different types of compounds were reviewed for their biological activities. In this review, we summarize numerous natural products for the development of MMPs inhibitors in arthritic diseases and describe the major signaling targets that were involved for the treatments of these destructive joint diseases.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32668590</pmid><doi>10.3390/ijms21144931</doi><orcidid>https://orcid.org/0000-0003-2056-4607</orcidid><orcidid>https://orcid.org/0000-0001-8265-3678</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Arthritis Biological effects Biological Products - therapeutic use Biomedical materials Cartilage Cartilage (articular) Cartilage diseases Cartilage, Articular - drug effects Cartilage, Articular - enzymology Cartilage, Articular - pathology Chondrocytes - drug effects Chondrocytes - enzymology Collagen Cytokines Cytokines - physiology Disease Drug Evaluation, Preclinical Drugs Enzymes Extracellular matrix Extracellular Matrix Proteins - metabolism Forecasting Gene expression Humans Inflammation Iodoacetic Acid - toxicity Joint diseases Joints (anatomy) Kinases Mammals Matrix metalloproteinase Matrix Metalloproteinase Inhibitors - therapeutic use Matrix metalloproteinases Models, Animal Natural products NF-kappa B - metabolism Osteoarthritis Osteoarthritis - chemically induced Osteoarthritis - drug therapy Osteoarthritis - enzymology Osteoarthritis - pathology Pain Pathophysiology Proteins Proteolysis Proteolytic enzymes Rats Review Rheumatoid arthritis Self Medication Signal transduction Studies Subchondral bone Tetradecanoylphorbol Acetate - toxicity Tumor necrosis factor-TNF |
| title | Molecular Targets of Natural Products for Chondroprotection in Destructive Joint Diseases |
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