Alk1 haploinsufficiency causes glomerular dysfunction and microalbuminuria in diabetic mice

Endothelial dysfunction has been shown to play an important role in the pathogenesis of glomerular damage during diabetic kidney disease (DKD). As such, a better understanding of the molecular mechanisms involved in glomerular endothelial dysfunctions could provide novel therapeutic strategies for t...

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Veröffentlicht in:	Scientific reports 2020-08, Vol.10 (1), p.13136-13136, Article 13136
Hauptverfasser:	Lora Gil, Cindy, Henley, Nathalie, Leblond, François A., Akla, Naoufal, Laurin, Louis-Philippe, Royal, Virginie, Gerarduzzi, Casimiro, Pichette, Vincent, Larrivée, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	631/80/304 692/4022/1585/2759/1419 Activin Receptors, Type II - genetics Activin Receptors, Type II - metabolism Albuminuria - genetics Albuminuria - metabolism Albuminuria - pathology Animals Apoptosis Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - genetics Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Female Haploinsufficiency Humanities and Social Sciences Humans Hyperglycemia Kidney diseases Kidney Glomerulus - metabolism Kidney Glomerulus - pathology Kidneys Male Mice Mice, Transgenic Molecular modelling multidisciplinary Renal function Rodents Science Science (multidisciplinary) Signal Transduction
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