Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage
Influenza vaccination can trigger various adverse reactions, and thrombocytopenia is also rarely reported. Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred...
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| Veröffentlicht in: | Internal Medicine 2020/07/01, Vol.59(13), pp.1633-1637 |
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| container_title | Internal Medicine |
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| creator | Yamamoto, Yuji Ohara, Yuko Iwai, Ami Hara, Reina Matsuki, Takanori Fukushima, Kiyoharu Oshitani, Yohei Kagawa, Hiroyuki Tsujino, Kazuyuki Yoshimura, Kenji Miki, Mari Miki, Keisuke Mori, Masahide Kida, Hiroshi |
| description | Influenza vaccination can trigger various adverse reactions, and thrombocytopenia is also rarely reported. Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred within one day of influenza vaccination and diffuse alveolar hemorrhage (DAH) leading to acute respiratory failure. The patient was treated with glucocorticoid pulse therapy, intravenous immunoglobulin, and temporary mechanical ventilation, and eventually he made a full recovery. Vaccine-related thrombocytopenia and DAH should be considered adverse reactions, even if they develop very soon after vaccination. |
| doi_str_mv | 10.2169/internalmedicine.3991-19 |
| format | Article |
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Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred within one day of influenza vaccination and diffuse alveolar hemorrhage (DAH) leading to acute respiratory failure. The patient was treated with glucocorticoid pulse therapy, intravenous immunoglobulin, and temporary mechanical ventilation, and eventually he made a full recovery. 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Med.</addtitle><description>Influenza vaccination can trigger various adverse reactions, and thrombocytopenia is also rarely reported. Although patients with mild thrombocytopenia are sometimes asymptomatic, severe thrombocytopenia can cause severe bleeding. We herein report a rare case of severe thrombocytopenia that occurred within one day of influenza vaccination and diffuse alveolar hemorrhage (DAH) leading to acute respiratory failure. The patient was treated with glucocorticoid pulse therapy, intravenous immunoglobulin, and temporary mechanical ventilation, and eventually he made a full recovery. Vaccine-related thrombocytopenia and DAH should be considered adverse reactions, even if they develop very soon after vaccination.</description><subject>acute respiratory failure</subject><subject>adverse reaction</subject><subject>Alveoli</subject><subject>Case Report</subject><subject>General & Internal Medicine</subject><subject>Glucocorticoids</subject><subject>Hemorrhage</subject><subject>Immunization</subject><subject>Influenza</subject><subject>Internal medicine</subject><subject>Intravenous administration</subject><subject>Life Sciences & Biomedicine</subject><subject>Mechanical ventilation</subject><subject>Medicine, General & Internal</subject><subject>Respiratory therapy</subject><subject>Science & Technology</subject><subject>Side effects</subject><subject>Thrombocytopenia</subject><subject>Vaccination</subject><subject>vaccine</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><recordid>eNqNkV9rFDEUxYModq1-hwFfBJmafzOTvAjLVm2h0JeqjyGTuelmmUnWJFOpn96suwxYX3y5CeR3DufmIFQRfEFJKz84nyF6PU4wOOM8XDApSU3kM7QijMu6o6x5jlZYElHTMs7Qq5R2GDPRSfoSnTFKhBC4WaHv196OM_hfuvqmTfHS2QVf65SCcTrDUK3NnKG628Yw9cE85rAH73Sl_VBdOmvnBNV6fIAw6lhdwRRi3Op7eI1eWD0meHM6z9HXz5_uNlf1ze2X6836pjYt57k2HLjUUmIpJLbS2NZijkHwVhBoLScwME4k6wc2dH1rNCaUScH7DlstTMvO0cej737uy28Y8DnqUe2jm3R8VEE79feLd1t1Hx5UxzGVLS4G704GMfyYIWU1uWRgHLWHMCdFWScxFU3TFfTtE3QX5kMNhSoheUu7rimUOFImhpQi2CUMwerQnnranjq0p8qWi_Qn9MEm48AbWOQY46YhhGFRblhuXP7T1SbMPhfp-_-XFvr2SO9SLmUtnI7ZmRH-TdhIRdhhnqIupNnqqMCz3wKm0SE</recordid><startdate>20200701</startdate><enddate>20200701</enddate><creator>Yamamoto, Yuji</creator><creator>Ohara, Yuko</creator><creator>Iwai, Ami</creator><creator>Hara, Reina</creator><creator>Matsuki, Takanori</creator><creator>Fukushima, Kiyoharu</creator><creator>Oshitani, Yohei</creator><creator>Kagawa, Hiroyuki</creator><creator>Tsujino, Kazuyuki</creator><creator>Yoshimura, Kenji</creator><creator>Miki, Mari</creator><creator>Miki, Keisuke</creator><creator>Mori, Masahide</creator><creator>Kida, Hiroshi</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Soc Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9767-7899</orcidid><orcidid>https://orcid.org/0000-0002-5489-5079</orcidid></search><sort><creationdate>20200701</creationdate><title>Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage</title><author>Yamamoto, Yuji ; Ohara, Yuko ; Iwai, Ami ; Hara, Reina ; Matsuki, Takanori ; Fukushima, Kiyoharu ; Oshitani, Yohei ; Kagawa, Hiroyuki ; Tsujino, Kazuyuki ; Yoshimura, Kenji ; Miki, Mari ; Miki, Keisuke ; Mori, Masahide ; Kida, Hiroshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c644t-c4e49a9909890f9cf6f040e84681e6f41ed34193bd3d7b6ca0123984b70fa8c63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>acute respiratory failure</topic><topic>adverse reaction</topic><topic>Alveoli</topic><topic>Case Report</topic><topic>General & Internal Medicine</topic><topic>Glucocorticoids</topic><topic>Hemorrhage</topic><topic>Immunization</topic><topic>Influenza</topic><topic>Internal medicine</topic><topic>Intravenous administration</topic><topic>Life Sciences & Biomedicine</topic><topic>Mechanical ventilation</topic><topic>Medicine, General & Internal</topic><topic>Respiratory therapy</topic><topic>Science & Technology</topic><topic>Side effects</topic><topic>Thrombocytopenia</topic><topic>Vaccination</topic><topic>vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Yuji</creatorcontrib><creatorcontrib>Ohara, Yuko</creatorcontrib><creatorcontrib>Iwai, Ami</creatorcontrib><creatorcontrib>Hara, Reina</creatorcontrib><creatorcontrib>Matsuki, Takanori</creatorcontrib><creatorcontrib>Fukushima, Kiyoharu</creatorcontrib><creatorcontrib>Oshitani, Yohei</creatorcontrib><creatorcontrib>Kagawa, Hiroyuki</creatorcontrib><creatorcontrib>Tsujino, Kazuyuki</creatorcontrib><creatorcontrib>Yoshimura, Kenji</creatorcontrib><creatorcontrib>Miki, Mari</creatorcontrib><creatorcontrib>Miki, Keisuke</creatorcontrib><creatorcontrib>Mori, Masahide</creatorcontrib><creatorcontrib>Kida, Hiroshi</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Yuji</au><au>Ohara, Yuko</au><au>Iwai, Ami</au><au>Hara, Reina</au><au>Matsuki, Takanori</au><au>Fukushima, Kiyoharu</au><au>Oshitani, Yohei</au><au>Kagawa, Hiroyuki</au><au>Tsujino, Kazuyuki</au><au>Yoshimura, Kenji</au><au>Miki, Mari</au><au>Miki, Keisuke</au><au>Mori, Masahide</au><au>Kida, Hiroshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage</atitle><jtitle>Internal Medicine</jtitle><stitle>INTERNAL MED</stitle><addtitle>Intern. 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| subjects | acute respiratory failure adverse reaction Alveoli Case Report General & Internal Medicine Glucocorticoids Hemorrhage Immunization Influenza Internal medicine Intravenous administration Life Sciences & Biomedicine Mechanical ventilation Medicine, General & Internal Respiratory therapy Science & Technology Side effects Thrombocytopenia Vaccination vaccine |
| title | Influenza Vaccination-associated Acute Thrombocytopenia and Diffuse Alveolar Hemorrhage |
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