Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression that suggest diverse host immune responses. We performed an integrated immune analysis on a cohort of 50 COVID-19 patients with various disease severity. A distinct phenotype was observed in severe and c...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2020-08, Vol.369 (6504), p.718-724
Hauptverfasser:	Hadjadj, Jérôme, Yatim, Nader, Barnabei, Laura, Corneau, Aurélien, Boussier, Jeremy, Smith, Nikaïa, Péré, Hélène, Charbit, Bruno, Bondet, Vincent, Chenevier-Gobeaux, Camille, Breillat, Paul, Carlier, Nicolas, Gauzit, Rémy, Morbieu, Caroline, Pène, Frédéric, Marin, Nathalie, Roche, Nicolas, Szwebel, Tali-Anne, Merkling, Sarah H, Treluyer, Jean-Marc, Veyer, David, Mouthon, Luc, Blanc, Catherine, Tharaux, Pierre-Louis, Rozenberg, Flore, Fischer, Alain, Duffy, Darragh, Rieux-Laucat, Frédéric, Kernéis, Solen, Terrier, Benjamin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Betacoronavirus - immunology Betacoronavirus - physiology Blood Coronavirus Infections - immunology Coronavirus Infections - virology Coronaviruses COVID-19 Critical Illness Cross-Sectional Studies Cytokines Damage Dendritic cells Disease Epithelium Failure Feedback (Response) Female Gene Expression Profiling Humans Immune system Immunity, Innate Immunology Individualized Instruction Infections Inflammation Inflammatory response Influenza Interferon Interferon alpha-2 - metabolism Interferon-alpha - metabolism Interferon-beta - metabolism Interleukin 6 Interleukin-6 - metabolism Life Sciences Lungs Male Microbio Middle Aged Morbidity Mucosa NF-kappa B - metabolism p53 Protein Pandemics Patients Peripheral blood Phenotypes Pneumonia, Viral - immunology Pneumonia, Viral - virology Repair Respiratory diseases Ribonucleic acid RNA SARS-CoV-2 Signal Transduction Signaling T-Lymphocyte Subsets - immunology Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumor necrosis factor-α Viral diseases Viral infections Viral Load α-Interferon β-Interferon
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