Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells

In this study the effect of histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) on the energetic status and cardiomyogenic differentiation of human healthy and dilated myocardium-derived mesenchymal stromal cells (hmMSC) have been investigated. The hmMSC were isolated from th...

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Veröffentlicht in:	International journal of molecular sciences 2020-07, Vol.21 (14), p.4845
Hauptverfasser:	Miksiunas, Rokas, Rucinskas, Kestutis, Janusauskas, Vilius, Labeit, Siegfried, Bironaite, Daiva
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actins - metabolism Adenosine triphosphate Adenosine Triphosphate - metabolism Antigens Calcium-binding protein Cardiomyopathy Cell adhesion & migration Cell Differentiation - drug effects Cell proliferation Cell Proliferation - drug effects Cells, Cultured Chemotherapy Differentiation Dilated cardiomyopathy Gene expression Heart Heart failure Histone deacetylase Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Histones Homeobox Homeobox Protein Nkx-2.5 - metabolism Humans Hydroxamic acid Inhibitors Membrane potential Membrane Potential, Mitochondrial - drug effects Membranes Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Mesenchyme Metabolism Mitochondria Mitochondria - drug effects Mitochondria - metabolism Morphology Mortality Myocardium Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Nkx2.5 protein Phosphorylation Proteins Respiration Stromal cells Troponin Troponin T Troponin T - metabolism Vorinostat - pharmacology
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